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Study of Viral Transduction of Human Auditory Sensory Cells for the Development of Gene Therapy

NCT03996824 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2024-09-19

No results posted yet for this study

Summary

Gene therapy is a promising strategy to treat hearing loss and vestibular disorders, and Associated adenovirus (AAV) is shown as a good viral vector for inner ear therapy in animal models.

This study aims to study in vitro viral transduction of AAV in human inner ear cells, collected during non-conservative surgeries for vestibular schwannoma.

Conditions

  • Hearing Loss, Sensorineural

Interventions

OTHER

Peroperative collect of inner ear cells

After obtaining an informed consent during the preoperative medical visit, and if a non-conservative approach (translabyrinthine or transotic) is decided, the collect of inner ear cells will be performed during surgical approach. The sample will be collect in a sterile tube, and carried to the laboratory were it will be placed bon cell culture.

Sponsors & Collaborators

  • Assistance Publique - Hôpitaux de Paris

    collaborator OTHER

  • Institut Pasteur

    lead INDUSTRY

Principal Investigators

  • Ghizlene Lahlou · Institut Pasteur

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-02-19
Primary Completion
2027-02-18
Completion
2027-02-18

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03996824 on ClinicalTrials.gov