PROCLAIM: CX-072-002: Study of PD-L1 Probody Therapeutic CX-072 in Combination With Other Anticancer Therapy in Adults With Solid Tumors
NCT03993379 · Status: TERMINATED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 3
Last updated 2025-12-26
Summary
To obtain evidence of antitumor effect of CX-072 in combination with anticancer therapy in adult patients with solid tumor based upon overall response rate by Response Evaluation Criteria in Solid Tumors (RECIST)
Conditions
- Solid Tumor
- Unresectable or Metastatic Melanoma
Interventions
- DRUG
-
CX-072
CX-072 in combination with ipilimumab
- DRUG
-
CX-072 in combination with ipilimumab
Sponsors & Collaborators
-
CytomX Therapeutics
lead INDUSTRY
Principal Investigators
-
Lawrence Lu, MD · CytomX Therapeutics
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2019-11-20
- Primary Completion
- 2020-05-21
- Completion
- 2020-05-21
- FDA Drug
- Yes
Countries
- United States
- Australia
- Netherlands
- South Korea
- Spain
Study Locations
More Related Trials
-
Optimization of the Patient Care Pathway in Immuno-oncology
NCT03329755 ·Status: COMPLETED ·Phase: NA
-
Study to Compare the Effect of Ipilimumab Retreatment With That of Chemotherapy in Advanced Melanoma
NCT01709162 ·Status: TERMINATED ·Phase: PHASE2
-
Study to Compare the Efficacy and Safety of CC-5013 vs. Placebo in Subjects With Metastatic Malignant Melanoma.
NCT00057616 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of PLX3397 in Patients With Unresectable or Metastatic KIT-mutated Melanoma
NCT02975700 ·Status: COMPLETED ·Phase: NA
-
Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of Investigational Treatments in Combination With Standard of Care Immune Checkpoint Inhibitors in Participants With Advanced Melanoma
NCT02723006 ·Status: TERMINATED ·Phase: PHASE1
-
A Phase I/II Open-Label Study of Ipilimumab and GM-CSF Administered to Unresectable Stage IIIC and Stage IV Melanoma Patients
NCT02009397 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Blocking TNF to Potentiate the ICI-dependent Immune Awakening in Melanoma
NCT05867004 ·Status: RECRUITING
-
Quality of Life and Physical Fitness After Immune Checkpoint Inhibitors
NCT03946007 ·Status: COMPLETED
-
Galectin Inhibitor (GR-MD-02) and Ipilimumab in Patients With Metastatic Melanoma
NCT02117362 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase II Trial of PD-L1 Therapy Combined With Anti-VEGF Therapy in Unresectable or Metastatic Melanoma
NCT04356729 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study to Assess Safety of Relatlimab With Ipilimumab in Participants With Advanced Melanoma Who Progressed on Anti-Programmed Cell Death Protein 1 (Anti-PD-1) Treatment
NCT03978611 ·Status: TERMINATED ·Phase: PHASE1
-
Ipilimumab With or Without Talimogene Laherparepvec in Unresected Melanoma
NCT01740297 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Assessment of Safety and Efficacy of OPM-101 Combined With Anti-PD-1 in Patients With Advanced Melanoma Showing Resistance to Anti-PD-1
NCT07040436 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
Study of Pembrolizumab (MK-3475) in Adults With Recurrent/Metastatic Cutaneous Squamous Cell Carcinoma (cSCC) or Locally Advanced Unresectable cSCC (MK-3475-629/KEYNOTE-629)
NCT03284424 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of MDX-010 (BMS-734016) Administered With or Without Prophylactic Oral Budesonide
NCT00135408 ·Status: COMPLETED ·Phase: PHASE2
-
Study of CBL0137 in Combination With Ipilimumab and Nivolumab Therapy in Melanoma
NCT05498792 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Intratumoral CAVATAK (CVA21) and Ipilimumab in Patients With Advanced Melanoma (VLA-013 MITCI)
NCT02307149 ·Status: COMPLETED ·Phase: PHASE1
-
Efficacy Study of Ipilimumab Versus Placebo to Prevent Recurrence After Complete Resection of High Risk Stage III Melanoma
NCT00636168 ·Status: COMPLETED ·Phase: PHASE3
-
Comparison of Ipilimumab Manufactured by 2 Different Processes in Participants With Advanced Melanoma
NCT00920907 ·Status: COMPLETED ·Phase: PHASE1
-
Long Term Quality of Life in Melanoma Patients in Netherlands
NCT03450876 ·Status: COMPLETED
-
A Phase 1/2 Randomized, Blinded, Placebo Controlled Study of Ipilimumab in Combination With Epacadostat or Placebo in Subjects With Unresectable or Metastatic Melanoma
NCT01604889 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Study of ONCOS-102 in Combination With Other Novel Immune-therapies in Advanced Treatment-resistant Melanoma Patients
NCT05561491 ·Status: WITHDRAWN ·Phase: PHASE2
-
Study of Alterations in Tumor Metabolism Associated With the Development of Immunotherapy Resistance in Melanoma
NCT05307289 ·Status: RECRUITING ·Phase: NA
-
Ipilimumab Induction in Patients With Melanoma Brain Metastases Receiving Stereotactic Radiosurgery
NCT02097732 ·Status: TERMINATED ·Phase: PHASE2
-
Ipilimumab With Carboplatin and Paclitaxel in Patients With Unresectable Stage III and Stage IV Melanoma
NCT01676649 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2