Trial Outcomes & Findings for Biomedical HIV/AIDS Prevention Program Yunnan (NCT NCT03992274)

NCT ID: NCT03992274

Last Updated: 2025-01-30

Results Overview

Number of clients who are aware of PrEP

Recruitment status

TERMINATED

Study phase

NA

Target enrollment

114 participants

Primary outcome timeframe

Up to 48 months

Results posted on

2025-01-30

Participant Flow

Participants include clients and staff. The study was conducted at 8 study sites Yunnan, China.

No participants or sites progressed beyond the Pre-Baseline.

Unit of analysis: sites

Participant milestones

Participant milestones
Measure
Sequence 1: 6 Months Pre-Baseline, Then 6 Months Baseline
Sequence 1: 6 months Pre-Baseline, 6 months Standard Implementation, 12 months Enhanced Implementation, and 6 months Post-Experiment Observation. Pre-Baseline: Routine Service with no PrEP Implementation. Baseline Period: Standard Implementation of PrEP. Experiment Period: Enhanced Implementation of PrEP.
Sequence 2: 6 Months Pre-Baseline, Then 12 Months Baseline
Sequence 2: 6 months Pre-Baseline, 6 months Standard Implementation, 12 months Enhanced Implementation, and 6 months Post-Experiment Observation Pre-Baseline: Routine Service with no PrEP Implementation. Baseline Period: Standard Implementation of PrEP. Experiment Period: Enhanced Implementation of PrEP.
Sequence 3: 6 Months Pre-Baseline, Then 18 Months Baseline
Sequence 3: 6 months Pre-Baseline, 18 months Standard Implementation, 12 months Enhanced Implementation, and 6 months Post-Experiment Observation Pre-Baseline: Routine Service with no PrEP Implementation. Baseline Period: Standard Implementation of PrEP. Experiment Period: Enhanced Implementation of PrEP.
Sequence 4: 6 Months Pre-Baseline, Then 24 Months Baseline
Sequence 4: 6 months Pre-Baseline, 24 months Standard Implementation, 12 months Enhanced Implementation, and 6 months Post-Experiment Observation Pre-Baseline: Routine Service with no PrEP Implementation. Baseline Period: Standard Implementation of PrEP. Experiment Period: Enhanced Implementation of PrEP.
Overall Study
STARTED
114 8
0 0
0 0
0 0
Overall Study
Clients
58 8
0 0
0 0
0 0
Overall Study
Staff
56 8
0 0
0 0
0 0
Overall Study
COMPLETED
114 8
0 0
0 0
0 0
Overall Study
NOT COMPLETED
0 0
0 0
0 0
0 0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Sex/Gender data were not collected from staff.

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure
Clients
n=58 Participants
MSM clients (men who have sex with men) who are involved in PrEP implementation
Staff
n=56 Participants
Program staff who are involved in PrEP implementation
Total
n=114 Participants
Total of all reporting groups
Age, Customized
>=18 years old
58 Participants
n=58 Participants
56 Participants
n=56 Participants
114 Participants
n=114 Participants
Sex: Female, Male
Female
0 Participants
n=58 Participants • Sex/Gender data were not collected from staff.
0 Participants
n=58 Participants • Sex/Gender data were not collected from staff.
Sex: Female, Male
Male
58 Participants
n=58 Participants • Sex/Gender data were not collected from staff.
58 Participants
n=58 Participants • Sex/Gender data were not collected from staff.
Ethnicity (NIH/OMB)
Hispanic or Latino
0 Participants
n=58 Participants
0 Participants
n=56 Participants
0 Participants
n=114 Participants
Ethnicity (NIH/OMB)
Not Hispanic or Latino
58 Participants
n=58 Participants
56 Participants
n=56 Participants
114 Participants
n=114 Participants
Ethnicity (NIH/OMB)
Unknown or Not Reported
0 Participants
n=58 Participants
0 Participants
n=56 Participants
0 Participants
n=114 Participants
Race (NIH/OMB)
American Indian or Alaska Native
0 Participants
n=58 Participants
0 Participants
n=56 Participants
0 Participants
n=114 Participants
Race (NIH/OMB)
Asian
58 Participants
n=58 Participants
56 Participants
n=56 Participants
114 Participants
n=114 Participants
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
0 Participants
n=58 Participants
0 Participants
n=56 Participants
0 Participants
n=114 Participants
Race (NIH/OMB)
Black or African American
0 Participants
n=58 Participants
0 Participants
n=56 Participants
0 Participants
n=114 Participants
Race (NIH/OMB)
White
0 Participants
n=58 Participants
0 Participants
n=56 Participants
0 Participants
n=114 Participants
Race (NIH/OMB)
More than one race
0 Participants
n=58 Participants
0 Participants
n=56 Participants
0 Participants
n=114 Participants
Race (NIH/OMB)
Unknown or Not Reported
0 Participants
n=58 Participants
0 Participants
n=56 Participants
0 Participants
n=114 Participants
Region of Enrollment
China
58 participants
n=58 Participants
56 participants
n=56 Participants
114 participants
n=114 Participants

PRIMARY outcome

Timeframe: Up to 48 months

Population: Due to the closure of the study and loss of funding, intervention was not implemented, and data was not collected or analyzed.

Number of clients who are aware of PrEP

Outcome measures

Outcome data not reported

PRIMARY outcome

Timeframe: Up to 48 months

Population: Due to the closure of the study and loss of funding, intervention was not implemented, and data was not collected or analyzed.

Number of clients who are eligible for PrEP

Outcome measures

Outcome data not reported

PRIMARY outcome

Timeframe: Up to 48 months

Population: Due to the closure of the study and loss of funding, intervention was not implemented, and data was not collected or analyzed.

Number of clients who are offered PrEP

Outcome measures

Outcome data not reported

PRIMARY outcome

Timeframe: Up to 48 months

Population: Due to the closure of the study and loss of funding, intervention was not implemented, and data was not collected or analyzed.

Number of clients initiating PrEP

Outcome measures

Outcome data not reported

PRIMARY outcome

Timeframe: Up to 48 months

Population: Due to the closure of the study and loss of funding, intervention was not implemented, and data was not collected or analyzed.

Number of PrEP initiators who remain PrEP-eligible and sustain use at six months

Outcome measures

Outcome data not reported

PRIMARY outcome

Timeframe: Up to 48 months

Population: Due to the closure of the study and loss of funding, intervention was not implemented, and data was not collected or analyzed.

The SIC is an 8-stage observational assessment tool recording organizational site completion of implementation activities that map onto the three phases of implementation (Pre-Implementation, Implementation, Sustainability). Proportion of PrEP implementation activities completed will be measured.

Outcome measures

Outcome data not reported

PRIMARY outcome

Timeframe: Up to 48 months

Population: Due to the closure of the study and loss of funding, intervention was not implemented, and data was not collected or analyzed.

The SIC is an 8-stage observational assessment tool recording organizational site completion of implementation activities that map onto the three phases of implementation (Pre-Implementation, Implementation, Sustainability). Time to completion of each implementation phase will be measured.

Outcome measures

Outcome data not reported

PRIMARY outcome

Timeframe: Up to 48 months

Population: Due to the closure of the study and loss of funding, intervention was not implemented, and data was not collected or analyzed.

Costs and resource allocation for completion of each implementation phase will be measured with the Cost of Implementing New Strategies (COINS) tool.

Outcome measures

Outcome data not reported

Adverse Events

Standard and Enhanced Implementation

Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Kathrine Meyers, DrPH, MPP, MSc

Columbia University

Phone: 2123046110

Results disclosure agreements

  • Principal investigator is a sponsor employee
  • Publication restrictions are in place