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Inhibiting Dietary Iron Absorption in Subjects With Hereditary Hemochromatosis by a Natural Polyphenol Supplement

NCT03990181 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 14

Last updated 2021-05-26

No results posted yet for this study

Summary

Polyphenolic compounds are very strong Inhibitors of non-heme iron absorption, as they form insoluble complexes with ferrous iron. Patients with hereditary hemochromatosis (HH) have an increased intestinal non-heme iron absorption due to a genetic mutation in the regulatory pathway, leading to excess iron in the body. This study investigates the inhibitory effect of a natural polyphenol Supplement in participants with HH.

Conditions

  • Iron Metabolism Disorders
  • Iron Overload
  • Polyphenols

Interventions

DIETARY_SUPPLEMENT

meal matrix & NPPS

Test meal consumed with the natural polyphenol supplement

DIETARY_SUPPLEMENT

meal matrix & CS

Test meal consumed with the control supplement

DIETARY_SUPPLEMENT

no-matrix & NPPS

Test drink consumed with the natural polyphenol supplement

DIETARY_SUPPLEMENT

no-matrix & CS

Test drink consumed with the control supplement

Sponsors & Collaborators

  • Instituto de Investigação em Imunologia

    collaborator OTHER

  • Swiss Federal Institute of Technology

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-09-20
Primary Completion
2020-08-15
Completion
2020-08-15

Countries

  • Portugal
  • Switzerland

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03990181 on ClinicalTrials.gov