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Application of Platelet Function Test in Prevention of Ischemic Events After Stent Placement in Intracranial Aneurysms

NCT03989557 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 314

Last updated 2020-09-09

No results posted yet for this study

Summary

This study was designed to identify high platelet reactivity (HPR) who might have in-stent thrombosis in unruptured aneurysm with intracranial stent placement with light transmittance platelet aggregometry (LTA). For HPR patients, higher ischemic stroke rate maybe occurred, and we hypothesis that dose adjustment of aspirin and clopidogrel based on LTA monitoring maybe reduces the rate of ischemic stroke compared to a standard strategy after intracranial stent implantation at early periprocedural period and 1 month follow-up period.

Conditions

  • Unruptured Intracranial Aneurysm
  • Stents
  • Antiplatelet Drugs

Interventions

DRUG

Aspirin and clopidogrel/Ticagrelor

The modification of aspirin and clopidogrel/ticagrelor maintenance doses based on a biomarker assays.

DEVICE

Light transmittance aggregometry

point-of-care method to assess platelet function by light transmittance aggregometry.

DRUG

Aspirin and clopidogrel/Ticagrelor

maintenance dose of aspirin, clopidogrel and ticagrelor.

Sponsors & Collaborators

  • Beijing Neurosurgical Institute

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-07-01
Primary Completion
2020-07-20
Completion
2020-08-13

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03989557 on ClinicalTrials.gov