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Prophylactic Administration of Alpha Blockers for Prevention of Urinary Retention in Males Undergoing Inguinal Hernia Repair Under Spinal Anaesthesia.

NCT03976934 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2021-11-26

No results posted yet for this study

Summary

Open inguinal hernia repair is one of the most common surgical procedures. Despite the fact that different of anesthetic procedures are proposed as alternatives to spinal anesthesia, the combination of spinal anesthesia with open inguinal hernia repair is preferred from both surgeons and patients. One disadvantage of this combination is the high incidence of post-surgery urinary retention, especially in men above 50 years old. This complication is partially attribute to overstimulation of the a1 adrenergic receivers of the bladder and the prostate. Preoperative administration of elective a1 blockers could inhibit this effect without side effects, since this drugs don't have systemic effect.

Conditions

  • Inguinal Hernia
  • Urinary Retention

Interventions

DRUG

Tamsulosin

administration of tamsulosin tablets

DRUG

Placebo oral tablet

sugar pills

Sponsors & Collaborators

  • University of Thessaly

    collaborator OTHER

  • Georgios Koukoulis

    lead OTHER

Principal Investigators

  • Konstantinos Tepetes, MD, PHD · University Hospital of Larisa and Medical School, University of Thessaly

  • Georgios D Koukoulis, MD, PhD · General Hospital of Larissa

  • Konstantinos Mpouliaris, MD · General Hospital of Larissa

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
50 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-02-01
Primary Completion
2021-10-01
Completion
2021-10-30

Countries

  • Greece

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03976934 on ClinicalTrials.gov