Optimizing HPV Vaccine Introduction in Shanghai, China

Summary

Within low, middle, and upper income countries, low vaccine coverage results from both obstacles to vaccine access and low confidence in vaccine programs. Thus, it is critical to determine how best to enhance trust in vaccines as increasing numbers of vaccines are recommended for use. Even though the context accompanying the initial roll-out of a vaccine can have a large impact on people's perceptions of the vaccine and the corresponding disease, it is not clear how to best introduce a vaccine to increase public confidence and enhance uptake. The US roll-out of the human papillomavirus (HPV) vaccine framed HPV as a sexually transmitted infection, which proved to be an impediment to efforts to increase vaccine uptake \>10 years after its introduction. This study will use an educational experiment, where parents of children will be exposed to information about the HPV vaccination in different ways. Parents will be introduced to the HPV vaccine through different scenarios with varying emphases (i.e., age at vaccination, types of transmission, type of cancer prevention). The aim will be to determine how the framing of the HPV vaccination across several dimensions affects short-term willingness to receive it.

Conditions

• Vaccine Refusal

Interventions

BEHAVIORAL

Broadened information about cancers

Caregivers receive information that HPV causes more than just cervical cancer.

BEHAVIORAL

Information about STDs

Caregivers learn that HPV is an STD.

BEHAVIORAL

Information about infectious disease

Caregivers learn that HPV is infectious (but information that it is an STD is omitted).

BEHAVIORAL

Recommendation for children 12 years old

Caregivers are prompted to get their child vaccinated when the child is 12 years old.

BEHAVIORAL

Recommendation for children 18 years old

Caregivers are prompted to get their child vaccinated when the child is 18 years old.

BEHAVIORAL

Standard age information

Caregivers are given information about when the HPV vaccination can be given in China, but no additional recommendations.

BEHAVIORAL

Cervical cancer

Caregivers are told that HPV causes cervical cancer.

BEHAVIORAL

Blank information about communicability

Caregivers are not given any information on how HPV is spread.

Sponsors & Collaborators

• Shanghai Municipal Center for Disease Control and Prevention

  collaborator OTHER

• National Institute of Allergy and Infectious Diseases (NIAID)

  collaborator NIH

• University of Michigan

  lead OTHER

Principal Investigators

• Abram L Wagner, PhD, MPH · University of Michigan

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

FACTORIAL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2019-05-28

Primary Completion

2019-08-31

Completion

2019-08-31

Countries

• China

Study Locations