The Impact of Abdominal Wall Closure Technique on Incidence of Incisional Hernia in Kidney Transplantation

Summary

STUDY SUMMARY Incisional hernias, or swellings of the abdominal scar after surgery, remain problematic especially after transplant surgery. This is because they can cause complications, including trapping of bowel or the transplant. This can cause life threatening emergencies but is at the very least unsightly and uncomfortable for the patient. Transplant patients are especially likely to develop hernias because of the diseases causing the renal failure and the drugs that they take to dampen the immune system. There is evidence from other surgery that the stitching methods that are used to close the wounds might decrease the risk of surgical hernias. This is achieved by placing smaller and more numerous sutures (stitches) in the wound to increase the strength of the repair. However, this has never been tested formally in transplant where it may provide significant benefit. We intend to do some initial investigation of whether using the smaller stitches may provide benefit over more traditional methods that are currently being used. We will look at early complications after surgery but also the rate of hernia formation later. We hope to improve outcomes and reduce complications for our transplant patients by doing this. In addition we will collect blood and tissue samples from both live kidney donors and the recipients to microscopically analyse their collagen to identify potential factors which may indicate risk of hernia formation.

Conditions

• Surgery--Complications

Interventions

PROCEDURE

Small stitch

Wound closure will be using small stiches or larger spaced stitches

OTHER

Blood sample

A blood sample to look for biological markers of Hernia formation will be taken

OTHER

Tissue Sample

A tissue sample will be taken to measure markers of wound healing.

OTHER

Pain Score

A pain score will be recorded following the surgical procedure.

OTHER

Quality of Life Score

A Quality of Life Score will be recorded at 1 month 6 months and 12 months post surgery

Sponsors & Collaborators

• Manchester University NHS Foundation Trust

  lead OTHER_GOV

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2020-03-10

Primary Completion

2026-06-30

Completion

2026-06-30

Countries

• United Kingdom

Study Locations