Clinical Research of ROBO1 Specific BiCAR-NK Cells on Patients With Pancreatic Cancer
NCT03941457 · Status: UNKNOWN · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 9
Last updated 2019-05-08
Summary
Immunotherapy has become the major breakthrough and the most promising treatment, with the host of development of tumor biology, molecular biology and immunology. ROBO1 is a potential target and spectacular paradigm in the treatment of solid tumors. This study is for evaluation of the safety and efficacy of ROBO1 CAR-NK cell immunotherapy for pancreatic cancer.
Conditions
Interventions
- BIOLOGICAL
-
BiCAR-NK cells (ROBO1 CAR-NK cells)
The subject will be observed for any side effects during this time and all the adverse events will be recorded.
Sponsors & Collaborators
-
Asclepius Technology Company Group (Suzhou) Co., Ltd.
lead INDUSTRY
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2019-05-31
- Primary Completion
- 2021-05-31
- Completion
- 2022-05-31
Countries
- China
Study Locations
More Related Trials
-
Personalized Tumor Neoantigen MRNA Therapy for Advanced Pancreatic Cancer.
NCT06888648 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
Ivonescimab(AK112/SMT112) in Combination With Stereotactic Body Radiation Therapy and Chemotherapy in Patients With Pancreatic Cancer
NCT06491472 ·Status: RECRUITING ·Phase: PHASE2
-
A Study to Evaluate the Efficacy and Safety of CT041 After Adjuvant Chemotherapy for Pancreatic Cancer
NCT05911217 ·Status: RECRUITING ·Phase: PHASE1
-
Newly Emerging Immunotherapy for Pancreatic Cancer Treatment
NCT06370754 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
Pembrolizumab Plus Chemotherapy in 1st Line Treatment of Pancreatic Cancer
NCT04447092 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
High-activity Natural Killer Immunotherapy for Small Metastases of Pancreatic Cancer
NCT03008304 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
CAR-NK Cells (CL-NK-001) in Pancreatic Cancer
NCT06816823 ·Status: RECRUITING ·Phase: PHASE1
-
Personalized Tumor Vaccines and Pabolizumab in Patients With Advanced Pancreatic Cancer
NCT05916261 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Ivonescimab With GnP and SBRT in Patients With Metastatic Pancreatic Cancer (WGOG-PAN 004)
NCT06991491 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Combination Immunotherapy Plus Standard-of-Care Chemotherapy Versus Standard-of-Care Chemotherapy for the Treatment of Locally Advanced or Metastatic Pancreatic Cancer
NCT04390399 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Antiangiogenic Peptide Vaccine Therapy With Gemcitabine in Treating Patient With Pancreatic Cancer (Phase1/2)
NCT00655785 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Nivolumab and All-trans Retinoic Acid for Pancreatic Cancer
NCT05482451 ·Status: ACTIVE_NOT_RECRUITING ·Phase: EARLY_PHASE1
-
Safety and Efficacy of NRT6008 in Patients With Unresectable Locally Advanced Pancreatic Cancer (LAPC)
NCT06278454 ·Status: RECRUITING ·Phase: PHASE1
-
Study of Personalized Tumour Vaccines and a PD-L1 Blocker in Patients With Surgically Resected Pancreatic Adenocarcino
NCT06156267 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
Vaccine Therapy in Treating Patients With Resected or Locally Advanced Unresectable Pancreatic Cancer
NCT00008099 ·Status: COMPLETED ·Phase: PHASE1
-
Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations
NCT06998940 ·Status: RECRUITING ·Phase: PHASE3
-
Nivolumab in Combination With Chemotherapy Pre-Surgery in Treating Patients With Borderline Resectable Pancreatic Cancer
NCT03970252 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Endoscopic Ultrasound (EUS) Intratumoral Injection of CAR-NK Cells in the Treatment of Advanced Pancreatic Cancer
NCT06478459 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Stereotactic Body Radiation Therapy Followed by NALIRIFOX vs NALIRIFOX for Borderline Resectable Pancreatic Cancer
NCT06259058 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
Irinotecan Liposome in Combination With 5-FU/LV Versus 5-FU/LV in Second-line Therapy for Gemcitabine-Refractory Pancreatic Cancer
NCT05074589 ·Status: COMPLETED ·Phase: PHASE3
-
SBRT Combined With Nimotuzumab and Mono-chemotherapy in Locally Advanced Pancreatic Cancer
NCT06422156 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Irinotecan Liposomes for the Treatment of Neuroendocrine Carcinoma
NCT06485739 ·Status: NOT_YET_RECRUITING ·Phase: PHASE4
-
Irinotecan Liposome in Combination With Capecitabine
NCT06578052 ·Status: RECRUITING ·Phase: NA
-
First-in-human Study of the Theranostic Pair [68Ga]Ga DOTA-5G and [177Lu]Lu DOTA-ABM-5G in Pancreatic Cancer
NCT04665947 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Study of Neoantigen mRNA Vaccines in Patients With Resectable Pancreatic Cancer
NCT06326736 ·Status: RECRUITING ·Phase: EARLY_PHASE1