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Improving Women's and Children's Health Via Biobanking and Electronic Registry

NCT03938129 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1976

Last updated 2022-05-24

No results posted yet for this study

Summary

Pregnancy related diseases and exposures in pregnancy are known risk factors for future disease. For example, women with a history of preeclampsia (a hypertensive disorder in pregnancy) and children born to these women are at increased risk of cardiovascular disease later in life. Yet, the mechanisms by which these long term health risks occur are unknown. Clearly, this presents a significant public health hazard as preventative and therapeutic interventions to block these pregnancy related diseases are limited. Current barriers to studying these long-term mechanisms in existing cohorts include 1) lack of paired long-term mother-child data, 2) lack of uniformly collected biosamples and 3) challenges in integrating data from multiple sources and institutions. In particular, data and biosample collection from rural and minority populations present significant challenges. The objective of the iELEVATE proposal is to expand and diversify a current biobank to accelerate long-term translational mechanistic and outcomes research in the vulnerable pregnancy population. We will accomplish this by establishing a widely available biorepository that will collect a first trimester blood and urine sample from pregnant women with a clinical data warehouse and e-registry to support long-term prospective cohort studies.

Conditions

  • Pregnancy Related
  • Maternal-Fetal Relations

Interventions

OTHER

Blood sample

1st trimester blood sample for bio-bank

OTHER

Urine sample

1st trimester urine sample for bio-bank

OTHER

Pregnancy, maternal health, and fetal health data

Pregnancy, maternal health, and fetal health data

Sponsors & Collaborators

  • National Institutes of Health (NIH)

    collaborator NIH

  • Mark Santillan

    lead OTHER

Principal Investigators

  • Mark Santillan, PhD, MD · University of Iowa

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-01-07
Primary Completion
2022-02-28
Completion
2022-02-28

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03938129 on ClinicalTrials.gov