DNA Exome Sequencing TCM for Sjögren's Syndrome

Summary

To explore the association among gene, TCM pattern, TCM tongue diagnosis and TCM pulse diagnosis with the DNA Exome sequencing tools for Sjögren's syndrome

Conditions

• Sjögren's Syndrome

Interventions

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DNA Exome sequencing

The DNA of Sjögren's syndrome patients and health subjects will take to do the DNA Exome sequencing.

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Oral microbiome

The saliva of Sjögren's syndrome patients and health subjects will take to do the oral microbiome.

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Proteomics

The protein of Sjögren's syndrome patients and health subjects will take to do the proteomics.

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RNA sequencing

The RNA of Sjögren's syndrome patients and health subjects will store to do the RNA sequencing.

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Cytokine

The serum of Sjögren's syndrome patients and health subjects will store to do the cytokine detection in the future.

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Traditional Chinese Medicine pattern

Sjögren's syndrome patients and health subjects will take the Traditional Chinese Medicine pattern.

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Traditional Chinese Medicine tongue diagnosis

Sjögren's syndrome patients and health subjects will take the Traditional Chinese Medicine tongue diagnosis.

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Traditional Chinese Medicine pulse diagnosis

Sjögren's syndrome patients and health subjects will take the Traditional Chinese Medicine pulse diagnosis.

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Heart rate variability

Sjögren's syndrome patients and health subjects will take the heart rate variability.

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Schirmer's test

Sjögren's syndrome patients will take the Schirmer's test.

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Blood function test, liver function test, kidney function test, and immune function test

Sjögren's syndrome patients and health subjects will take the blood function test (WBC, RBC, Hb, HCT, Platelet, MCV, MCH, and MCHC), liver function test (AST and ALT), kidney function test (BUN and Cre), and immune function test (RF, Anti-SSA, Anti-SSB Ab, ESR, and CRP)

Sponsors & Collaborators

• Taipei Veterans General Hospital, Taiwan

  lead OTHER_GOV

Principal Investigators

• Ching-Mao Chang, M.D., Ph.D. · Taipei Veterans General Hospital, Taiwan

Eligibility

Min Age

20 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2019-04-01

Primary Completion

2019-05-15

Completion

2019-12-31

Countries

• Taiwan

Study Locations