The PAH Platform for Deep Phenotyping in Korean Subjects

Summary

A total of 16 regional hospitals will be registering clinical data and biological specimens of idiopathic pulmonary arterial hypertension (IPAH)/heritable pulmonary arterial hypertension (HPAH) patients across Korea. The diagnosis of pulmonary arterial hypertension(PAH) will be based on right heart catheterization, where PAH caused by etiology other than HPAH or IPAH will be excluded. All clinical data will be stored to a government-based online database. Each participating hospitals will be collecting whole blood from each patient, through which DNA, RNA, serum, plasma, and peripheral blood mononuclear cells will be extracted from the buffy coat layer for further multi-omics analysis.

Conditions

• Pulmonary Arterial Hypertension
• Deep Phenotyping
• Idiopathic Pulmonary Arterial Hypertension
• Heritable Pulmonary Arterial Hypertension

Interventions

DIAGNOSTIC_TEST

Deep phenotyping

Each participating hospitals will be collecting whole blood from each patient, through which DNA, RNA, serum, plasma, and peripheral blood mononuclear cells will be extracted from the buffy coat layer for further multi-omics analysis.

Sponsors & Collaborators

• Sejong General Hospital

  collaborator OTHER

• Chonnam National University Hospital

  collaborator OTHER

• Keimyung University Dongsan Medical Center

  collaborator OTHER

• Saint Vincent's Hospital, Korea

  collaborator OTHER

• Seoul National University

  collaborator OTHER

• Chungnam National University Hospital

  collaborator OTHER

• Wonju Severance Christian Hospital

  collaborator OTHER

• Asan Medical Center

  collaborator OTHER

• Wonkwang University Hospital

  collaborator OTHER

• Chungbuk National University Hospital

  collaborator OTHER

• Samsung Medical Center

  collaborator OTHER

• Severance Hospital

  collaborator OTHER

• The Catholic University of Korea

  collaborator OTHER

• Seoul National University Bundang Hospital

  collaborator OTHER

• Pusan National University Hospital

  collaborator OTHER

• Chonbuk National University Hospital

  collaborator OTHER

• Pusan National University Yangsan Hospital

  collaborator OTHER

• Gachon University Gil Medical Center

  lead OTHER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-03-01

Primary Completion

2020-12-31

Completion

2020-12-31

Countries

• South Korea

Study Locations