Trial Outcomes & Findings for Targeting Attention Orienting to Social Threat to Reduce Social Anxiety in Youth (NCT NCT03932032)
NCT ID: NCT03932032
Last Updated: 2026-04-29
Results Overview
Posttreatment event related potential amplitude elicited during the emotional faces dot probe task. The investigators focused specifically on the P1 amplitude time-locked to the onset of emotional facial stimuli in the dot probe task. P1 amplitude was measured using EEG methodology. Higher scores indicate greater allocation of neural resources when viewing stimuli in the dot probe task, which can be interpreted as an indicator of greater attention orientation to emotional facial stimuli.
COMPLETED
NA
206 participants
post-intervention (within one week of completing the final treatment session)
2026-04-29
Participant Flow
Participant milestones
| Measure |
Neutral Control Task
Neutral Control Task uses the same computer-based format as Attention Bias Modification Treatment, but includes only neutral stimuli and does not train attention.
|
Attention Bias Modification Treatment
Attention Bias Modification Treatment is a computer-based attention training program.
|
|---|---|---|
|
Overall Study
STARTED
|
101
|
105
|
|
Overall Study
COMPLETED
|
89
|
97
|
|
Overall Study
NOT COMPLETED
|
12
|
8
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Targeting Attention Orienting to Social Threat to Reduce Social Anxiety in Youth
Baseline characteristics by cohort
| Measure |
Attention Bias Modification Treatment
n=105 Participants
Attention Bias Modification Treatment is a computer-based attention training program.
|
Neutral Control Task
n=101 Participants
Neutral Control Task uses the same computer-based format as Attention Bias Modification Treatment, but includes only neutral stimuli and does not train attention.
|
Total
n=206 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Continuous
|
11.78 age in years
STANDARD_DEVIATION 1.44 • n=9 Participants
|
11.82 age in years
STANDARD_DEVIATION 1.61 • n=24 Participants
|
11.80 age in years
STANDARD_DEVIATION 1.53 • n=23 Participants
|
|
Sex: Female, Male
Female
|
64 Participants
n=9 Participants
|
63 Participants
n=24 Participants
|
127 Participants
n=23 Participants
|
|
Sex: Female, Male
Male
|
41 Participants
n=9 Participants
|
38 Participants
n=24 Participants
|
79 Participants
n=23 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=9 Participants
|
1 Participants
n=24 Participants
|
1 Participants
n=23 Participants
|
|
Race (NIH/OMB)
Asian
|
5 Participants
n=9 Participants
|
1 Participants
n=24 Participants
|
6 Participants
n=23 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=9 Participants
|
0 Participants
n=24 Participants
|
0 Participants
n=23 Participants
|
|
Race (NIH/OMB)
Black or African American
|
10 Participants
n=9 Participants
|
11 Participants
n=24 Participants
|
21 Participants
n=23 Participants
|
|
Race (NIH/OMB)
White
|
72 Participants
n=9 Participants
|
74 Participants
n=24 Participants
|
146 Participants
n=23 Participants
|
|
Race (NIH/OMB)
More than one race
|
16 Participants
n=9 Participants
|
13 Participants
n=24 Participants
|
29 Participants
n=23 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
2 Participants
n=9 Participants
|
1 Participants
n=24 Participants
|
3 Participants
n=23 Participants
|
|
Ethnicity (NIH/OMB)
Hispanic or Latino
|
54 Participants
n=9 Participants
|
51 Participants
n=24 Participants
|
105 Participants
n=23 Participants
|
|
Ethnicity (NIH/OMB)
Not Hispanic or Latino
|
49 Participants
n=9 Participants
|
49 Participants
n=24 Participants
|
98 Participants
n=23 Participants
|
|
Ethnicity (NIH/OMB)
Unknown or Not Reported
|
2 Participants
n=9 Participants
|
1 Participants
n=24 Participants
|
3 Participants
n=23 Participants
|
|
P1 amplitude elicited in the dot-probe task
|
6.56 microvolts
STANDARD_DEVIATION 4.14 • n=9 Participants
|
5.92 microvolts
STANDARD_DEVIATION 4.75 • n=24 Participants
|
6.23 microvolts
STANDARD_DEVIATION 4.47 • n=23 Participants
|
|
Liebowitz Social Anxiety Scale for Children and Adolescents
|
99.29 units on a scale
STANDARD_DEVIATION 22.01 • n=9 Participants
|
101.98 units on a scale
STANDARD_DEVIATION 23.86 • n=24 Participants
|
100.66 units on a scale
STANDARD_DEVIATION 22.92 • n=23 Participants
|
PRIMARY outcome
Timeframe: post-intervention (within one week of completing the final treatment session)Posttreatment event related potential amplitude elicited during the emotional faces dot probe task. The investigators focused specifically on the P1 amplitude time-locked to the onset of emotional facial stimuli in the dot probe task. P1 amplitude was measured using EEG methodology. Higher scores indicate greater allocation of neural resources when viewing stimuli in the dot probe task, which can be interpreted as an indicator of greater attention orientation to emotional facial stimuli.
Outcome measures
| Measure |
Neutral Control Task
n=89 Participants
Neutral Control Task uses the same computer-based format as Attention Bias Modification Treatment, but includes only neutral stimuli and does not train attention.
|
Attention Bias Modification Treatment
n=97 Participants
Attention Bias Modification Treatment is a computer-based attention training program.
|
|---|---|---|
|
P1 Amplitude Elicited in the Dot-probe Task
|
5.61 microvolts
Standard Deviation 4.34
|
7.04 microvolts
Standard Deviation 4.85
|
PRIMARY outcome
Timeframe: Follow-up (six months after completing the final treatment session)Follow-up P1 event related potential amplitude elicited during the emotional faces dot probe task. The investigators focused specifically on the P1 amplitude time-locked to the onset of emotional facial stimuli in the dot probe task. P1 amplitude was measured using EEG methodology. Higher scores indicate greater allocation of neural resources when viewing stimuli in the dot probe task, which can be interpreted as an indicator of greater attention orientation to emotional facial stimuli.
Outcome measures
| Measure |
Neutral Control Task
n=89 Participants
Neutral Control Task uses the same computer-based format as Attention Bias Modification Treatment, but includes only neutral stimuli and does not train attention.
|
Attention Bias Modification Treatment
n=97 Participants
Attention Bias Modification Treatment is a computer-based attention training program.
|
|---|---|---|
|
P1 Amplitude Elicited in the Dot-probe Task
|
4.98 microvolts
Standard Deviation 4.52
|
5.64 microvolts
Standard Deviation 4.34
|
SECONDARY outcome
Timeframe: post-intervention (within one week of completing the final treatment session)posttreatment clinician rating of youth social anxiety symptom severity. A single rating is made to characterize overall social anxiety symptom severity aggregated over the past 7 days. The name of the measure is the Liebowitz Social Anxiety Scale for Children and Adolescents. It is a clinician rated measure of the severity of youths' social anxiety symptoms. Total scores range from 0 to 144, with higher scores representing more severe social anxiety.
Outcome measures
| Measure |
Neutral Control Task
n=89 Participants
Neutral Control Task uses the same computer-based format as Attention Bias Modification Treatment, but includes only neutral stimuli and does not train attention.
|
Attention Bias Modification Treatment
n=97 Participants
Attention Bias Modification Treatment is a computer-based attention training program.
|
|---|---|---|
|
Liebowitz Social Anxiety Scale for Children and Adolescents
|
87.55 units on a scale
Standard Deviation 28.65
|
84.22 units on a scale
Standard Deviation 26.93
|
SECONDARY outcome
Timeframe: Follow-up (six months after completing the final treatment session)Follow-up clinician rating of youth social anxiety symptom severity. A single rating is made to characterize overall social anxiety symptom severity aggregated over the past 7 days. The name of the measure is the Liebowitz Social Anxiety Scale for Children and Adolescents. It is a clinician rated measure of the severity of youths' social anxiety symptoms. Total scores range from 0 to 144, with higher scores representing more severe social anxiety.
Outcome measures
| Measure |
Neutral Control Task
n=89 Participants
Neutral Control Task uses the same computer-based format as Attention Bias Modification Treatment, but includes only neutral stimuli and does not train attention.
|
Attention Bias Modification Treatment
n=97 Participants
Attention Bias Modification Treatment is a computer-based attention training program.
|
|---|---|---|
|
Liebowitz Social Anxiety Scale for Children and Adolescents
|
76.06 units on a scale
Standard Deviation 35.07
|
74.76 units on a scale
Standard Deviation 31.94
|
SECONDARY outcome
Timeframe: post-intervention (within one week of completing the final treatment session)posttreatment parent rating of youth social anxiety symptom severity. A single rating is made to characterize overall social anxiety symptom severity aggregated over the past 7 days. The name of the measure is the Screen for Child Anxiety Related Emotional Disorders - Parent Version (SCARED-P). The SCARED-P is a parent rated measure of the severity of youths' anxiety symptoms, including social anxiety. Total scores on the SCARED-P range from 0 to 82, with higher scores representing more severe anxiety.
Outcome measures
| Measure |
Neutral Control Task
n=89 Participants
Neutral Control Task uses the same computer-based format as Attention Bias Modification Treatment, but includes only neutral stimuli and does not train attention.
|
Attention Bias Modification Treatment
n=97 Participants
Attention Bias Modification Treatment is a computer-based attention training program.
|
|---|---|---|
|
Screen for Child Anxiety Related Emotional Disorders - Parent Version at Posttreatment
|
27.69 units on a scale
Standard Deviation 13.16
|
28.73 units on a scale
Standard Deviation 14.38
|
SECONDARY outcome
Timeframe: Follow-up (six months after completing the final treatment session)follow up parent rating of youth social anxiety symptom severity. A single rating is made to characterize overall social anxiety symptom severity aggregated over the past 7 days. The name of the measure is the Screen for Child Anxiety Related Emotional Disorders - Parent Version (SCARED-P). The SCARED-P is a parent rated measure of the severity of youths' anxiety symptoms, including social anxiety. Total scores on the SCARED-P range from 0 to 82, with higher scores representing more severe anxiety.
Outcome measures
| Measure |
Neutral Control Task
n=89 Participants
Neutral Control Task uses the same computer-based format as Attention Bias Modification Treatment, but includes only neutral stimuli and does not train attention.
|
Attention Bias Modification Treatment
n=97 Participants
Attention Bias Modification Treatment is a computer-based attention training program.
|
|---|---|---|
|
Screen for Child Anxiety Related Emotional Disorders - Parent Version at Follow up
|
22.43 units on a scale
Standard Deviation 12.81
|
24.82 units on a scale
Standard Deviation 14.94
|
SECONDARY outcome
Timeframe: post-intervention (within one week of completing the final treatment session)posttreatment child rating of youth social anxiety symptom severity. A single rating is made to characterize overall social anxiety symptom severity aggregated over the past 7 days. The name of the measure is the Screen for Child Anxiety Related Emotional Disorders - Child Version (SCARED-C). The SCARED-C is a child rated measure of the severity of youths' anxiety symptoms, including social anxiety. Total scores on the SCARED-C range from 0 to 82, with higher scores representing more severe anxiety.
Outcome measures
| Measure |
Neutral Control Task
n=89 Participants
Neutral Control Task uses the same computer-based format as Attention Bias Modification Treatment, but includes only neutral stimuli and does not train attention.
|
Attention Bias Modification Treatment
n=97 Participants
Attention Bias Modification Treatment is a computer-based attention training program.
|
|---|---|---|
|
Screen for Child Anxiety Related Emotional Disorders - Child Version at Posttreatment
|
27.68 units on a scale
Standard Deviation 19.16
|
31.89 units on a scale
Standard Deviation 18.01
|
SECONDARY outcome
Timeframe: Follow-up (six months after completing the final treatment session)Follow up child rating of youth social anxiety symptom severity. A single rating is made to characterize overall social anxiety symptom severity aggregated over the past 7 days. The name of the measure is the Screen for Child Anxiety Related Emotional Disorders - Child Version (SCARED-C). The SCARED-C is a child rated measure of the severity of youths' anxiety symptoms, including social anxiety. Total scores on the SCARED-C range from 0 to 82, with higher scores representing more severe anxiety.
Outcome measures
| Measure |
Neutral Control Task
n=89 Participants
Neutral Control Task uses the same computer-based format as Attention Bias Modification Treatment, but includes only neutral stimuli and does not train attention.
|
Attention Bias Modification Treatment
n=97 Participants
Attention Bias Modification Treatment is a computer-based attention training program.
|
|---|---|---|
|
Screen for Child Anxiety Related Emotional Disorders - Child Version at Follow-Up
|
20.79 units on a scale
Standard Deviation 18.33
|
28.25 units on a scale
Standard Deviation 17.85
|
OTHER_PRE_SPECIFIED outcome
Timeframe: post-intervention (within one week of completing the final treatment session)posttreatment State-Trait Anxiety Inventory for Children - State Subscale (STAIC-S) administered before a 3-minute speech task. Participants were told that they would give a video-recorded speech about their strengths and weaknesses for three minutes, and then given three minutes to prepare for the speech. At the end of the three-minute preparation period, participants were administered the STAIC-S. The STAIC-S measures state (momentary) levels of anxiety. Total scores range from 20 to 60, with higher scores indicating higher levels of anxiety.
Outcome measures
| Measure |
Neutral Control Task
n=89 Participants
Neutral Control Task uses the same computer-based format as Attention Bias Modification Treatment, but includes only neutral stimuli and does not train attention.
|
Attention Bias Modification Treatment
n=97 Participants
Attention Bias Modification Treatment is a computer-based attention training program.
|
|---|---|---|
|
State Anxiety Before a Speech Task
|
34.87 units on a scale
Standard Deviation 7.81
|
36.38 units on a scale
Standard Deviation 8.02
|
OTHER_PRE_SPECIFIED outcome
Timeframe: Follow-up (six months after completing the final treatment session)Follow-up State-Trait Anxiety Inventory for Children - State Subscale (STAIC-S) administered before a 3-minute speech task. Participants were told that they would give a video-recorded speech about their strengths and weaknesses for three minutes, and then given three minutes to prepare for the speech. At the end of the three-minute preparation period, participants were administered the STAIC-S. The STAIC-S measures state (momentary) levels of anxiety. Total scores range from 20 to 60, with higher scores indicating higher levels of anxiety.
Outcome measures
| Measure |
Neutral Control Task
n=89 Participants
Neutral Control Task uses the same computer-based format as Attention Bias Modification Treatment, but includes only neutral stimuli and does not train attention.
|
Attention Bias Modification Treatment
n=97 Participants
Attention Bias Modification Treatment is a computer-based attention training program.
|
|---|---|---|
|
State Anxiety Before a Speech Task
|
33.93 units on a scale
Standard Deviation 8.11
|
35.66 units on a scale
Standard Deviation 8.68
|
OTHER_PRE_SPECIFIED outcome
Timeframe: post-intervention (within one week of completing the final treatment session)posttreatment State-Trait Anxiety Inventory for Children - State Subscale (STAIC-S) administered after a 3-minute speech task. Participants were told that they would give a video-recorded speech about their strengths and weaknesses for three minutes, and then given three minutes to prepare for the speech. At the end of the three-minute preparation period, participants gave the speech. After giving the speech, they were administered the STAIC-S. The STAIC-S measures state (momentary) levels of anxiety. Total scores range from 20 to 60, with higher scores indicating higher levels of anxiety.
Outcome measures
| Measure |
Neutral Control Task
n=89 Participants
Neutral Control Task uses the same computer-based format as Attention Bias Modification Treatment, but includes only neutral stimuli and does not train attention.
|
Attention Bias Modification Treatment
n=97 Participants
Attention Bias Modification Treatment is a computer-based attention training program.
|
|---|---|---|
|
State Anxiety After a Speech Task
|
34.12 units on a scale
Standard Deviation 8.15
|
35.39 units on a scale
Standard Deviation 8.42
|
OTHER_PRE_SPECIFIED outcome
Timeframe: 6 months after completing the final treatment sessionfollow-up State-Trait Anxiety Inventory for Children - State Subscale (STAIC-S) administered after a 3-minute speech task. Participants were told that they would give a video-recorded speech about their strengths and weaknesses for three minutes, and then given three minutes to prepare for the speech. At the end of the three-minute preparation period, participants gave the speech. After giving the speech, they were administered the STAIC-S. The STAIC-S measures state (momentary) levels of anxiety. Total scores range from 20 to 60, with higher scores indicating higher levels of anxiety.
Outcome measures
| Measure |
Neutral Control Task
n=89 Participants
Neutral Control Task uses the same computer-based format as Attention Bias Modification Treatment, but includes only neutral stimuli and does not train attention.
|
Attention Bias Modification Treatment
n=97 Participants
Attention Bias Modification Treatment is a computer-based attention training program.
|
|---|---|---|
|
State Anxiety After a Speech Task
|
33.16 units on a scale
Standard Deviation 8.05
|
33.75 units on a scale
Standard Deviation 8.95
|
Adverse Events
Attention Bias Modification Treatment
Neutral Control Task
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place