B Cell Maturation Antigen(BMCA)-Targeted CAR-T for Refractory/Relapsed Multiple Myeloma
NCT03931421 · Status: UNKNOWN · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 30
Last updated 2019-06-04
Summary
It's a single arm, open label prospective study, in which the safety and efficacy of B Cell Maturation Antigen(BMCA)-targeted CAR-T thearpy are evaluated in refractory/relapsed multiple myeloma patients.
Conditions
Interventions
- BIOLOGICAL
-
CAR-T treatment
a novel method for treatment of multiple myeloma, in which patients' T cells are engineered into B Cell Maturation Antigen(BMCA)-Targeted CAR-T cells to eliminate myeloma cells.
Sponsors & Collaborators
-
First Affiliated Hospital of Zhejiang University
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2019-07-31
- Primary Completion
- 2022-11-30
- Completion
- 2022-12-31
Countries
- China
Study Locations
More Related Trials
-
Clinical Study of CAR-BCMA T in Patients With Refractory or Relapsed Multiple Myeloma
NCT03716856 ·Status: UNKNOWN ·Phase: PHASE1
-
Chimeric Antigen Receptor Modified T Cells Targeting BCMA for the Treatment of Relapsed/Refractory Multiple Myeloma
NCT06581640 ·Status: RECRUITING ·Phase: PHASE2
-
Clinical Study of CAR-BCMA T Cells in Patients With Refractory or Relapsed Multiple Myeloma
NCT03380039 ·Status: UNKNOWN ·Phase: NA
-
BCMA-Targeted CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma and Plasma Cell Disease
NCT04271644 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
BCMA-CAR-T in Relapsed/Refractory Multiple Myeloma
NCT03664661 ·Status: UNKNOWN ·Phase: PHASE1
-
A Study of Humanized BCMA-targeted CAR-T Cells Therapy for Refractory/Relapsed Multiple Myeloma
NCT04670055 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
BCMA Chimeric Antigen Receptor Expressing T Cells Therapy for Relapsed/Refractory Multiple Myeloma
NCT03943472 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
Study of BCMA CAR-T in Multiple Myeloma
NCT03322735 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Humanized CAR-T Cells of Anti-BCAM and Anti-CD19 Against Relapsed and Refractory Multiple Myeloma
NCT04194931 ·Status: UNKNOWN ·Phase: PHASE1
-
Anti-BCMA CAR-T Cell Therapy for the R/R Multiple Myeloma
NCT04637269 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
A Study of BCMA-directed CAR-T Cells Treatment in Subjects With r/r Multiple Myeloma
NCT03751293 ·Status: UNKNOWN ·Phase: PHASE1
-
Safety and Efficacy of IM21 Car-t Cells in Patients With Recurrent or Refractory BCMA Positive Multiple Myeloma
NCT03711864 ·Status: UNKNOWN ·Phase: PHASE1
-
Human BCMA Targeted T Cells Injection(BCMA CAR-T)for Subjects With R/R MM
NCT05594797 ·Status: RECRUITING ·Phase: PHASE2
-
Sequential CAR-T Cells Targeting BCMA/GPRC5D in Patients With Relapsed/ Refractory Multiple Myeloma
NCT07032129 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Clinical Research of Adoptive BCMA CAR-NK Cells on Relapse/Refractory MM
NCT03940833 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
CAR-T Re-treatment for Refractory/Relapsed Multiple Myeloma
NCT03672253 ·Status: UNKNOWN ·Phase: PHASE1
-
Immunotherapy With BCMA CAR-T Cells in Treating Patients With Relapsed or Refractory Multiple Myeloma
NCT04447573 ·Status: UNKNOWN ·Phase: NA
-
A Study of BCMA-directed CAR-T Cells Treatment in Subjects With r/r Multiple Myeloma
NCT03815383 ·Status: UNKNOWN ·Phase: PHASE1
-
Phase I Trial of BCMA-TGF-BETA CAR-T Cells in Relapsed, Refractory Myeloma
NCT05976555 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
A Study of Anti-BCMA CAR-T Therapy in Newly Diagnosed Myeloma Patients Who Are Transplant-ineligible
NCT07070960 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
BCMA Chimeric Antigen Receptor Expressing T Cells in Multiple Myeloma
NCT03093168 ·Status: UNKNOWN ·Phase: PHASE1
-
Study of T Cells Targeting CD138/BCMA/CD19/More Antigens (CART-138/BCMA/19/More) for Chemotherapy Refractory and Relapsed Multiple Myeloma
NCT03196414 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Clinical Study of T Cell Infusion Targeting BCMA Chimeric Antigen Receptor
NCT04650724 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Safety and Efficacy of Anti-BCMA/FcRL5 CAR-T Cell Therapy in Treating Relapsed and Refractory Multiple Myeloma (R/R MM)
NCT06759181 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of BCMA-directed CAR-T Cells Treatment in Subjects With r/r Multiple Myeloma
NCT04322292 ·Status: COMPLETED ·Phase: PHASE1