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Screening for Systemic Amyloidosis Via the Ligamentum Flavum

NCT03923920 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2021-12-22

No results posted yet for this study

Summary

The investigators will prospectively evaluate for the presence of amyloid deposits in ligamentum flavum (yellow ligament) tissue samples obtained from patients undergoing spinal stenosis surgery. Patients who have tissue that stains positive for amyloid will be referred to an amyloidosis specialist.

Conditions

  • Amyloid
  • Amyloidosis
  • Spinal Stenosis
  • Transthyretin Amyloidosis
  • Primary Amyloidosis of Light Chain Type

Interventions

PROCEDURE

Biopsy

During clinically-scheduled spinal stenosis surgery, ligamentum flavum tissue (which may contain surrounding tissue and subcutaneous fat) that is removed during the procedure will be sent to pathology to be analyzed with amyloid-specific staining.

Sponsors & Collaborators

  • The Cleveland Clinic

    lead OTHER

Principal Investigators

  • Mazen A Hanna, MD · The Cleveland Clinic

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-05-01
Primary Completion
2021-10-04
Completion
2021-12-02

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03923920 on ClinicalTrials.gov