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Overcoming Psychomotor Slowing in Psychosis (OCoPS-P)

NCT03921450 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 103

Last updated 2023-02-14

No results posted yet for this study

Summary

Psychomotor slowing is a major problem in psychosis. Aberrant function of the cerebral motor system is linked to psychomotor slowing in patients, particularly resting state hyperactivity in premotor cortices. A previous clinical trial indicated that inhibitory stimulation of the premotor cortex would reduce psychomotor slowing. The current study is further exploring this effect in a randomized, placebo-controlled, double-blind design with three arms of transcranial magnetic stimulation and measures of brain imaging and physiology prior to and after the intervention.

Conditions

  • Schizophrenia and Related Disorders
  • Schizophrenia
  • Schizoaffective Disorder
  • Brief Psychotic Disorder

Interventions

DEVICE

1 Hz rTMS

1 Hz stimulation at 110% of resting motor threshold over supplementary motor area

DEVICE

iTBS

50 Hz theta burst stimulation at 80% of resting motor threshold over supplementary motor area

DRUG

Placebo

1 Hz stimulation with the placebo TMS coil without any magnetic emission

Sponsors & Collaborators

  • University of Bern

    lead OTHER

Principal Investigators

  • Sebastian Walther, MD · University of Bern

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-03-25
Primary Completion
2022-11-01
Completion
2023-02-10

Countries

  • Switzerland

Study Locations

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Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03921450 on ClinicalTrials.gov