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Neurostimulation and OCD, a MRI Study

NCT03918837 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2025-10-06

No results posted yet for this study

Summary

This study will focus on the use of repetitive Transcranial Magnetic Stimulation (rTMS) as a treatment of Obsessive Compulsive Disorder (OCD), which is a common illness that impairs quality of life and that can be hard to treat.

To precisely analyze the effects of rTMS on OCD, the investigators are going to plan a study comparing cerebral blood flow before and after rTMS treatment. The measuring will occur on the Orbito Frontal Cortex (OFC), whose role in OCD has already been shown by our team (Nauczyciel et al, 2014 in Translational Psychiatry), using Magnetic Resonance Imaging in Arterial Spin Labeling, an MRI method allowing to measure arteriola blood flow.

Our primary outcome is to show a significate difference between cerebral blood flow in OCD between one group of participants treated by rTMS and another one treated by placebo. The study will be double blinded with a placebo rTMS machine, monocentric and prospective, with participants suffering from OCD randomized between two groups.

Conditions

  • Obsessive Compulsive Disorder

Interventions

OTHER

Sham rTMS

Participants will undergo sham rTMS for five days with two daily fifteen minutes rTMS sessions.

OTHER

Active rTMS

Participants will undergo active rTMS for five days with two daily fifteen minutes rTMS sessions.

Sponsors & Collaborators

  • Fondation de l'Avenir

    collaborator OTHER

  • Hospital Center Guillaume Régnier

    lead OTHER

Principal Investigators

  • Dominique DRAPIER, MD PHD · Centre Hospitalier Guillaume Régnier

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-04-26
Primary Completion
2022-06-24
Completion
2022-06-24

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03918837 on ClinicalTrials.gov