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Serum Copeptin as a Predictor of the Risk of Hyponatremia After Transurethral Prostatectomy

NCT03912766 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 43

Last updated 2019-04-11

No results posted yet for this study

Summary

Hyponatremic hypovolemia is a frequent complication of transurethral resection of the prostate gland (TURP). Copeptin has been established as is a surrogate marker of vasopressin and is measured useful for thea clinical assessment of various sodium and water disturbances. The aim of our the study was to assess the utility of serum concentration of copeptin (CPP) and brain natriuretic peptide (NT-proBNP) for the prediction of postoperative alterations of serum sodium concentration. Study population comprised 43 patients with benign prostatic hyperplasia (BPH) undergoing transurethral resection of the prostate gland. In a forward stepwise multiple regression only serum copeptin before the surgery and the duration of TURP significantly explained the variation of sodium concentration for 12 hours from the start of the surgery. Serum NT-proBNP before the surgery did not predict hyponatremia 12 hours after TURP.Conclusion Serum copeptin before TURP surgery but not NT-proBNP may be a clinically useful marker of a decrease of serum sodium after TURP surgery.

Conditions

  • Benign Prostatic Hyperplasia

Interventions

DIAGNOSTIC_TEST

serum copeptin

routine surgical method using resectoscope inserted into the urinary bladder

Sponsors & Collaborators

  • Medical University of Lodz

    lead OTHER

Principal Investigators

  • Michal Nowicki, MD PhD · Medical University of Lodz

Eligibility

Min Age
40 Years
Max Age
80 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-02-01
Primary Completion
2017-01-02
Completion
2018-03-30

Countries

  • Poland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03912766 on ClinicalTrials.gov