Chronic Myloid Leukemic Patients Treated With Tyrosine Kinase Inhibitor
NCT03907670 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 45
Last updated 2019-09-30
Summary
The aim of the study is to assesse the levels of various biomarkers, specifically interleukin (IL)-6, platelet-derived microparticles (PDMPs), 11, 12 soluble vascular cell adhesion molecule 1 (sVCAM-1), transforming growth factor (TGF) β1, and sCTLA-4, in TKI-treated patients with CML.
To measure the fluctuations in the levels of sCTLA-4, TGFβ1, and PDMPs, and to clarify the clinical significance of these biomarkers during TKI therapy in patients with CML..
Conditions
- Chronic Phase Chronic Myelogenous Leukemia
Sponsors & Collaborators
-
Assiut University
lead OTHER
Eligibility
- Min Age
- 20 Years
- Max Age
- 80 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2019-10-01
- Primary Completion
- 2020-10-01
- Completion
- 2021-10-01
More Related Trials
-
Interleukin 11, Thrombocytopenia, Imatinib in Chronic Myelogenous Leukemia (CML) Patients
NCT00493181 ·Status: COMPLETED ·Phase: PHASE2
-
Discontinuation of TyrosIne Kinase Inhibitors (TKI) in Chronic Myeloid Leukemia (CML) and Impact on the Immune System
NCT05753384 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
A Study of Treatment-free Remission in Chronic Phase Chronic Myeloid Leukemia
NCT06368414 ·Status: RECRUITING ·Phase: PHASE2
-
TyrosIne Kinase Inhibitors in Chronic Myeloid Leukemia: Efficacy and Tolerability. The TIKlet Study
NCT01860456 ·Status: COMPLETED
-
Asciminib Treatment Optimization in ≥ 3rd Line CML-CP
NCT04948333 ·Status: COMPLETED ·Phase: PHASE3
-
A Real-world Chronic Myelogenous Leukemia (CML) Patient Disease Registry to Describe Patient Experience and Clinical Outcomes Among Patients With CML Receiving Approved First or Second Line Tyrosine Kinase Inhibitor (TKI) Therapy
NCT07091019 ·Status: NOT_YET_RECRUITING
-
A Study of Oral Asciminib Versus Other TKIs in Adult Patients With Newly Diagnosed Ph+ CML-CP
NCT04971226 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Study of Efficacy and Safety of CML-CP Patients Treated With Asciminib Versus Best Available Therapy, Previously Treated With 2 or More Tyrosine Kinase Inhibitors
NCT04795427 ·Status: COMPLETED ·Phase: PHASE2
-
Asciminib as Initial Therapy for Patients With Chronic Myeloid Leukemia in Chronic Phase
NCT05143840 ·Status: RECRUITING ·Phase: PHASE2
-
Safety Study Evaluating Intravenous Infusions of Tigecycline to Treat Acute Myeloid Leukemia
NCT01332786 ·Status: COMPLETED ·Phase: PHASE1
-
S9031-S9333-S0112-S0301-A Biomarkers Associated With Response to Cytarabine in Samples From Older Patients With Acute Myeloid Leukemia
NCT01338974 ·Status: COMPLETED
-
Condition Vasoregulation Function Endothelium in Patients With CML Getting TKI II Generation Bosutinib
NCT05682924 ·Status: RECRUITING
-
Studying Biomarkers in Cell Samples From Young Patients With Acute Myeloid Leukemia
NCT01057290 ·Status: COMPLETED
-
The Efficacy and Safety of Induction-Maintenance Protocol for Patients With Chronic Myelogenous Leukaemia
NCT03241199 ·Status: UNKNOWN ·Phase: PHASE2
-
Interaction Between Gut Microbiota and TKIs in Defining the Clinical Outcomes of Patients With CML
NCT06724536 ·Status: RECRUITING
-
Efficacy, Safety and Long-term Prognosis of Imatinib in Patients Newly Diagnosed With Chronic Myelogenous Leukemia (Chronic Phase)
NCT00237120 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of Imatinib and Valproic Acid in Patients With Chronic Myelogenous Leukemia (CML)
NCT01011998 ·Status: WITHDRAWN ·Phase: PHASE2
-
Study of Treatment Free Remission in Patients With Chronic Myeloid Leukemia in Chronic Phase
NCT05926128 ·Status: UNKNOWN ·Phase: NA
-
Imatinib Discontinuation in Patients With Chronic Myeloid Leukemia Chronic Phase With Sustained MR4log
NCT03239886 ·Status: UNKNOWN ·Phase: NA
-
Precision Dosing of Tyrosine Kinase Inhibitors in CML Patients
NCT03885830 ·Status: COMPLETED
-
Studying First Line Treatment of Chronic Myeloid Leukemia (CML) in a Real-world Setting
NCT01244750 ·Status: COMPLETED
-
Study Conducted Among Patients With CML
NCT05476562 ·Status: COMPLETED
-
Study of Efficacy of CML-CP Patients Treated With ABL001 Versus Bosutinib, Previously Treated With 2 or More TKIs
NCT03106779 ·Status: COMPLETED ·Phase: PHASE3
-
Real-World Treatment Patterns and Outcomes Among Patients With Chronic Myeloid Leukemia in Earlier Lines of Therapy
NCT06692803 ·Status: COMPLETED
-
Treatment Free Remission After Combination Therapy With Ruxolitinib Plus Tyrosine Kinase Inhibitors
NCT03610971 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2