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Influence of Dopaminergic Blockade on Stress Responses, Motivation and Emotional Reactivity in Humans.

NCT03863691 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 85

Last updated 2020-09-21

No results posted yet for this study

Summary

The study aims to identify whether partial blockade of human dopamine signaling with antipsychotic drugs affects human stress responses, motivation and emotion. 84 healthy adult participants are planned to complete the study protocol.

Therefore three experiments are planned:

Experiment 1: Influence of amisulpride on human stress responses. Experiment 2: Influence of amisulpride on motivated effort. Experiment 3: Influence of amisulpride on emotion.

Conditions

  • Healthy Participants

Interventions

DRUG

Amisulpride 300 MG

A single dose of 300 mg amisulpride that looks identical to placebo control capsules.

DRUG

Placebo oral capsule

A placebo capsule with no inert pharmacological effect. Looks identical to the amisulpride capsules.

Sponsors & Collaborators

  • University of Hamburg-Eppendorf

    collaborator OTHER

  • Philipps University Marburg

    lead OTHER

Principal Investigators

  • Winfried Rief, Professor · Philipps-Univeristy of Marburg

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-04-15
Primary Completion
2020-07-15
Completion
2020-07-15

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03863691 on ClinicalTrials.gov