Mechanisms of Rumination Change in Adolescent Depression

Summary

This study will evaluate whether a newer treatment, rumination-focused cognitive behavioral treatment, which includes mindfulness and can be used to reduce ruminative habits, change ways in which key brain regions interact with each other (e.g.., often called connectivity), and whether these changes in habits and brain connectivity can reduce the risk for recurrence of depression in the next two years.

Conditions

• Major Depressive Disorder
• Mood Disorders

Interventions

BEHAVIORAL

Rumination-Focused CBT

RF-CBT targets rumination and other maladaptive forms of emotion regulation such as suppression and avoidance and provides skills training in effectively coping with rumination. RF-CBT specifically targets rumination through psychoeducation, adopting a functional analytic approach to the learned habitual behavior of rumination, and a focus on shifting process style. The adolescent is taught to notice triggers to ruminate as well as the consequences of rumination and to shift into practicing a more adaptive strategy such as an attention training exercise, behavioral activation, thinking in a concrete way, or active problem-solving. RF-CBT directly teaches adolescents to recognize rumination or "when the participant gets stuck in their head" and to notice the influence this has on their mood.

BEHAVIORAL

Relaxation-based Therapy

Sessions will include progressive muscle relaxation, simple breathing techniques, and guided imagery that focus on bodily and somatic relaxation. Adolescents randomized to Relaxation Therapy (RelaxT) will also receive exercises to do as homework in between sessions, parallel to the RF-CBT group.

Sponsors & Collaborators

• University of Exeter

  collaborator OTHER

• National Institute of Mental Health (NIMH)

  collaborator NIH

• University of Utah

  collaborator OTHER

• Nationwide Children's Hospital

  collaborator OTHER

• Utah Center for Evidence Based Treatment

  collaborator UNKNOWN

• Ohio State University

  lead OTHER

Principal Investigators

• Scott Langenecker, Ph.D. · Ohio State University

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

14 Years

Max Age

17 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-05-01

Primary Completion

2028-04-14

Completion

2029-03-02

Countries

• United States

Study Locations