Pyrotinib in Combination With Trastuzumab in Treatment-refractory, HER2-positive Metastatic Colorectal Cancar.
NCT03843749 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30
Last updated 2019-02-18
Summary
This clinical trial aims to evaluate the efficacy, safety of Pyrotinib in combination with trastuzumab in Treatment-refractory, HER2-positive Metastatic Colorectal Cancar.
Conditions
Interventions
- DRUG
-
Pyrotinib
Pyrotinib in Combination With Trastuzumab
Sponsors & Collaborators
-
Shanghai Changzheng Hospital
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2019-07-01
- Primary Completion
- 2019-07-01
- Completion
- 2022-07-01
Countries
- China
Study Locations
More Related Trials
-
S0304 Induct Chemo Then Chemo-RT in Pts w/Locally Advanced Adenocarcinoma of the Rectum
NCT00070434 ·Status: WITHDRAWN ·Phase: PHASE2
-
Efficacy of FOLFOX+Bevacizumab in Combination With Irinotecan in the Treatment of Metastatic Colorectal Cancer
NCT01321957 ·Status: COMPLETED ·Phase: PHASE2
-
Trifluridine/Tipiracil Plus Regorafenib vs Trifluridine/Tipiracil Plus Bevacizumab for Refractory Metastatic Colorectal Cancer
NCT06992648 ·Status: RECRUITING ·Phase: PHASE3
-
Fruquintinib and Pirfenidone in Combination With Anti-PD-1 Antibody in Advanced or Metastatic pMMR/MSS Colorectal Carcinoma
NCT06484153 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of Systemic Chemotherapy With CPT-11 Plus HAI (FUDR+L-OHP) in Patients With Initially Unresectable CRCLM
NCT03493061 ·Status: COMPLETED ·Phase: PHASE2
-
Safety Study of Oxaliplatin and 5-fluorouracil Followed by FUDR for Unresectable Colorectal Liver Metastases
NCT00557557 ·Status: COMPLETED ·Phase: PHASE1
-
5FU/LV, Irinotecan, Temozolomide and Bevacizumab for MGMT Silenced, Microsatellite Stable Metastatic Colorectal Cancer.
NCT04689347 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Genotype-guided Study of Irinotecan Administered in Combination With 5-fluorouracil/Leucovorin (FOLFIRI) and Bevacizumab in Advanced Colorectal Cancer Patients
NCT01183494 ·Status: COMPLETED ·Phase: PHASE1
-
Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer
NCT00006115 ·Status: UNKNOWN ·Phase: PHASE2
-
Phase I / II Study of Irinotecan (CPT-11) Combined With l-Leucovorin (l-LV) and 5-FU in Patients With Advanced Colorectal Cancer
NCT00209625 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
ctDNA-guided Treatment of TKI Plus PD-1 Inhibitor for Advanced pMMR/MSS Colorectal Cancer
NCT06543836 ·Status: RECRUITING ·Phase: PHASE2
-
Endostar Combined With mFOLFOX6 for First-line Treatment of Metastatic Colorectal Cancer
NCT01832948 ·Status: UNKNOWN ·Phase: PHASE2
-
Irinotecan Compared With Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer
NCT00005036 ·Status: COMPLETED ·Phase: PHASE3
-
Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies
NCT01643499 ·Status: COMPLETED ·Phase: PHASE1
-
Fruquintinib Combined With Chemotherapy as Third-line /Third-line+ Treatment in Advanced Colorectal Cancer
NCT05928312 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
FOLFIRI or mFOLFOX6 in Adjuvant Chemotherapy in Advanced Colorectal Cancer
NCT01566942 ·Status: UNKNOWN ·Phase: PHASE3
-
FOLFIRI Versus Irinotecan as Second-line Treatment in Metastatic Colorectal Cancer Patients
NCT02935764 ·Status: UNKNOWN ·Phase: PHASE3
-
Neoadjuvant FOLFOXIRI Chemotherapy in Resectable Liver Metastasis of Colorectal Cancer
NCT03487939 ·Status: UNKNOWN ·Phase: PHASE2
-
Irinotecan/Oxaliplatin/5-Fluorouracil/Leucovorin/Cetuximab As First Line Treatment In Colorectal Cancer
NCT00689624 ·Status: COMPLETED ·Phase: PHASE2
-
Trifluridine/Tipiracil Plus Fruquintinib vs. Trifluridine/Tipiracil Plus Bevacizumab in Refractory Metastatic Colorectal Cancer: A Randomized, Controlled, Open-Label, Non-Inferiority Trial
NCT07261709 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
A Prospective, Multicenter Randomized Controlled Study of the Application of Preoperative FOLFOXIRI Chemotherapy Combined With Lateral Lymph Node Dissection in Low- and Medium-lying Rectal Cancer With Lateral Lymph Node Metastasis
NCT06048146 ·Status: COMPLETED ·Phase: NA
-
Rechallenge of Prior Regimen in Third or Later-line Chemotherapy in Metastatic Colorectal Cancer
NCT03485027 ·Status: COMPLETED ·Phase: PHASE2
-
Erlotinib and Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer
NCT00049101 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Irinotecan With or Without Panitumumab or Cyclosporine in Treating Patients With Advanced or Metastatic Colorectal Cancer That Did Not Respond to Fluorouracil
NCT00389870 ·Status: COMPLETED ·Phase: PHASE3
-
Induction Chemotherapy Followed by Short Course Radiotherapy in Rectal Cancer
NCT05868317 ·Status: UNKNOWN ·Phase: PHASE2