MedTrace Logo

The Impact of Coronary Chronic Total Occlusion Percutaneous Coronary Intervention on Culprit Vessel Physiology

NCT03830853 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2021-12-21

No results posted yet for this study

Summary

Following successful CTO PCI, a multitude of physiological and anatomical changes take place. Contemporary techniques such as dissection/re-entry or lumen-lumen wiring may influence the immediate and longer term follow up of these features. It is not known whether changes in this level of physiology and anatomy in the context of CTO vessels correlate with each other, or with quality of life and exercise capacity.

This study aims to take physiological measurements of absolute coronary flow, resistance and pressure and intra-coronary imaging immediately after successful CTO PCI. The investigators will relate these to each other and to the method of revascularisation, comparing changes in these groups at three months follow up.

QoL measurements, and exercise testing will be carried out to see if there is a relationship between physiological and anatomical changes with exercise capacity and quality of life.

Results from this study could shed light on optimisation of CTO PCI procedural and clinical outcomes.

Conditions

  • Chronic Total Occlusion of Coronary Artery

Sponsors & Collaborators

  • Brighton and Sussex University Hospitals NHS Trust

    collaborator OTHER

  • Mid and South Essex NHS Foundation Trust

    lead OTHER

Principal Investigators

  • John Davies, MBBS, PhD · Basildon and Thurrock University Hospitals

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-01-23
Primary Completion
2018-01-01
Completion
2018-01-01

Countries

  • United Kingdom

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03830853 on ClinicalTrials.gov