Trial Outcomes & Findings for Exercise Training to Improve Cognitive Function (NCT NCT03824639)

Last Updated: 2024-02-14

Results Overview

Wechsler Logical Memory Task is a recall test involving 2 short stories. Possible scores on the delayed recall task range from 0 (no details recalled for both stories) to 50 (all details recalled on both stories). Outcome is change in the delayed recall score from baseline to 6 months.

Recruitment status

COMPLETED

Study phase

Target enrollment

60 participants

Primary outcome timeframe

baseline and 6 months

Results posted on

2024-02-14

Participant Flow

Participant milestones

Participant milestones
Measure	Exercise Group Structured exercise Structured exercise: Exercise instruction and encouragement	Control Group Health education Health Education: Provision of general information about a variety of health topics
Overall Study STARTED	29	31
Overall Study COMPLETED	29	31
Overall Study NOT COMPLETED	0	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Exercise Training to Improve Cognitive Function

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Exercise Group n=29 Participants Structured exercise Structured exercise: Exercise instruction and encouragement	Control Group n=31 Participants Health education Health Education: Provision of general information about a variety of health topics	Total n=60 Participants Total of all reporting groups
Age, Categorical <=18 years	0 Participants n=99 Participants	0 Participants n=107 Participants	0 Participants n=206 Participants
Age, Categorical Between 18 and 65 years	4 Participants n=99 Participants	4 Participants n=107 Participants	8 Participants n=206 Participants
Age, Categorical >=65 years	25 Participants n=99 Participants	27 Participants n=107 Participants	52 Participants n=206 Participants
Sex: Female, Male Female	2 Participants n=99 Participants	2 Participants n=107 Participants	4 Participants n=206 Participants
Sex: Female, Male Male	27 Participants n=99 Participants	29 Participants n=107 Participants	56 Participants n=206 Participants
Ethnicity (NIH/OMB) Hispanic or Latino	0 Participants n=99 Participants	0 Participants n=107 Participants	0 Participants n=206 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	29 Participants n=99 Participants	31 Participants n=107 Participants	60 Participants n=206 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	0 Participants n=99 Participants	0 Participants n=107 Participants	0 Participants n=206 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=99 Participants	0 Participants n=107 Participants	0 Participants n=206 Participants
Race (NIH/OMB) Asian	0 Participants n=99 Participants	0 Participants n=107 Participants	0 Participants n=206 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=99 Participants	0 Participants n=107 Participants	0 Participants n=206 Participants
Race (NIH/OMB) Black or African American	3 Participants n=99 Participants	1 Participants n=107 Participants	4 Participants n=206 Participants
Race (NIH/OMB) White	26 Participants n=99 Participants	30 Participants n=107 Participants	56 Participants n=206 Participants
Race (NIH/OMB) More than one race	0 Participants n=99 Participants	0 Participants n=107 Participants	0 Participants n=206 Participants
Race (NIH/OMB) Unknown or Not Reported	0 Participants n=99 Participants	0 Participants n=107 Participants	0 Participants n=206 Participants
Wechsler Logical Memory Task	10.3 units on a scale STANDARD_DEVIATION 5.6 • n=99 Participants	9.5 units on a scale STANDARD_DEVIATION 7.1 • n=107 Participants	9.9 units on a scale STANDARD_DEVIATION 6.4 • n=206 Participants
Rey-Osterrieth Complex Figure Test	9.0 units on a scale STANDARD_DEVIATION 4.6 • n=99 Participants	7.6 units on a scale STANDARD_DEVIATION 5.2 • n=107 Participants	8.3 units on a scale STANDARD_DEVIATION 5.0 • n=206 Participants

PRIMARY outcome

Timeframe: baseline and 6 months

Outcome measures

Outcome measures
Measure	Exercise Group n=29 Participants Structured exercise Structured exercise: Exercise instruction and encouragement	Control Group n=31 Participants Health education Health Education: Provision of general information about a variety of health topics
Change in Delayed Recall Score on Wechsler Logical Memory Task From Baseline to 6 Months	0.74 units on a scale Standard Deviation 4.0	-0.87 units on a scale Standard Deviation 4.7

SECONDARY outcome

Timeframe: baseline and 6 months

Rey-Osterrieth Complex Figure Test is a recall test involving a complex figure. Possible scores on the delayed recall task range from 0 (no accurate details recalled for the figure) to 36 (all details accurately recalled for the figure). Outcome is change in the delayed recall score from baseline to 6 months.

Outcome measures

Outcome measures
Measure	Exercise Group n=29 Participants Structured exercise Structured exercise: Exercise instruction and encouragement	Control Group n=31 Participants Health education Health Education: Provision of general information about a variety of health topics
Change in Delayed Recall Score on the Rey-Osterrieth Complex Figure Test From Baseline to 6 Months	1.18 units on a scale Standard Deviation 4.5	0.46 units on a scale Standard Deviation 3.3

Adverse Events

Exercise Group

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Control Group

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Dr. David Sparrow

VA Boston Healthcare System

Phone: 857-364-6400

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place