MedTrace Logo

High Definition Endoscopy With NBI. Contribution in Patients With Non-erosive Esophagitis

NCT03824431 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 70

Last updated 2019-02-15

No results posted yet for this study

Summary

Most patients with symptomatic gastroesophageal reflux disease (GERD) have a normal upper gastrointestinal endoscopy. Attempts have been made to define new endoscopic techniques for identification of abnormalities non detected in standard endoscopic exam. The high definition endoscopy with NBI could achieve a more detailed mucosal evaluation, allowing distal esophageal microerosions identification.

The objective was validate the presence and the meaning of distal esophageal mucosal microerosions using high definition endoscopy and NBI through esophageal biopsy in gastroesophageal reflux disease symptomatic patients and the association with GERD physiopathology.

Seventy patients were selected from the gastroenterology outpatient clinic (University of Sao Paulo Hospital) Endoscopic evaluation was sequentially performed after the pHmetry and esophageal manometry. Esophageal mucosal biopsies were obtained following established protocol for histological and immunohistochemical study.

Conditions

  • GERD

Interventions

DIAGNOSTIC_TEST

Endoscopic esophageal biopsies

Sponsors & Collaborators

  • University of Sao Paulo

    collaborator OTHER

  • University of Sao Paulo General Hospital

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-01-23
Primary Completion
2016-11-04
Completion
2018-11-20

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03824431 on ClinicalTrials.gov