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Induction Chemotherapy for Locally Advanced Head and Neck Squamous Cell Carcinoma

NCT03815903 · Status: RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 434

Last updated 2019-07-18

No results posted yet for this study

Summary

The benefit of induction chemotherapy followed by chemoradiotherapy for locally advanced head and neck squamous cell carcinoma is unknown. The present study is investigating if this therapeutic strategy improve overall survival.

Conditions

  • Locally Advanced Malignant Neoplasm

Interventions

DRUG

Induction chemotherapy

3 cycles, each 21 days, of Cisplatin 80mg/m2 plus Paclitaxel 175mg/m2

COMBINATION_PRODUCT

Chemoradiotherapy

Radiotherapy 70Gy convencional fractionation concomitant to 3 cycles, each 21 days, of Cisplatin 100mg/m2

Sponsors & Collaborators

  • Barretos Cancer Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-12-19
Primary Completion
2020-12-31
Completion
2025-12-31

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03815903 on ClinicalTrials.gov