Validation Study of the Simplified Seizure Classification Algorithm

Summary

An algorithm has been developed for simplified classification of epileptic seizures, in order to optimize choice of antiepileptic drugs.

The objective of this study was to clinically validate the algorithm.

Conditions

• Epilepsy

Interventions

DIAGNOSTIC_TEST

EpiPick simplified seizure classification algorithm

EpiPick simplified seizure classification algorithm input: Grey matter brain lesion Exclusively nocturnal seizures First seizure at age \> 20 years Lip smacking or chewing during seizures Staring with impaired awareness, lasting less than 20s without postictal confusion Sudden irregular jerks, in isolation or brief series, if none of the following applies: Are the jerks consistently in the same limb? When resting in bed when falling asleep? Bilateral tonic-clonic seizures within 1h of awakening or immediately preceded by irregular jerks Any of the following is present: Skin turning pale pre-ictally; Loss of consciousness immediately after urination or defecation; Sudden slump with loss of awareness, lasting less than 10 seconds; Seizure lasting longer than 10 minutes, with eyes closed throughout the seizure; Severe pre-ictal headache; Episodes consisting of falls that occur always after change in posture to the upright position, or coughing or feeling pain.

Sponsors & Collaborators

• Danish Epilepsy Centre

  collaborator UNKNOWN

• Shiraz University of Medical Sciences

  collaborator OTHER

• University of Pavia

  collaborator OTHER

• Thomas Jefferson University

  collaborator OTHER

• Sándor Beniczky

  lead OTHER

Principal Investigators

• Sandor Beniczky, MD, PhD · Aarhus University Hospital

• Guido Rubboli, MD, PhD · Danich Epilepsy Centre

• Michael Sperling, MD, PhD · Thomas Jefferson University

• Emilio Perucca, MD, PhD · University of Pavia

• Ali A Asadi-Pooya, MD, PhD · Shiraz University of Medical Sciences

Eligibility

Min Age

10 Years

Max Age

120 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-06-02

Primary Completion

2020-12-31

Completion

2020-12-31

Countries

• United States
• Denmark
• Iran
• Italy

Study Locations