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Predicting Pancreatic Necrosis Using mitDNA

NCT03788928 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 25

Last updated 2018-12-28

No results posted yet for this study

Summary

Multiple predictors have been used for early pancreatic necrosis, prediction, detection, and monitoring. These include clinical score systems and circulating biomarkers. Ranson and APACHE II score systems are widely used albeit complex and time-consuming. Recently, the role of circulating biomarkers . Of these novel biomarkers, only CRP has been used routinely in cases of pancreatic necrosis prediction. Mitochondrial DNA (mtDNA) is an extra chromosomal genome occurring in the mitochondria of eukaryotic cells. High levels of mtDNA suggest the presence of pancreatic necrosis and close observation should be given to avoid the development of SAP and pancreatitis infection.

Conditions

  • Pancreatic Necrosis

Interventions

DIAGNOSTIC_TEST

serum mitochondrial DNA

serum mitochondrial DNA will be measured using RT-PCR within first 72 hours of symptoms of acute pancreatitis

Sponsors & Collaborators

  • Assiut University

    lead OTHER

Eligibility

Min Age
16 Years
Max Age
70 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-01-31
Primary Completion
2020-01-31
Completion
2020-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03788928 on ClinicalTrials.gov