Lenvatinib Plus PD-1 Antibody for Intermediate-stage HCC Beyond Up-to-seven Criteria
NCT03775707 · Status: WITHDRAWN · Phase: PHASE2 · Type: INTERVENTIONAL
Last updated 2019-05-06
Summary
The purpose of this study is to evaluate the efficacy and safety of lenvatinib combined with PD-1 antibody for patients with intermediate-stage hepatocellular carcinoma (HCC) beyond up-to-seven criteria
Conditions
Interventions
- DRUG
-
12 mg (or 8 mg) once daily (QD) oral dosing.
- DRUG
-
PD-1 antibody
3mg/kg intravenously every 2 weeks
Sponsors & Collaborators
-
Shi Ming
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2018-12-01
- Primary Completion
- 2019-12-01
- Completion
- 2019-12-01
Countries
- China
Study Locations
More Related Trials
-
Lenvatinib Combined Pembrolizumab in Advanced Hepatobiliary Tumors
NCT03895970 ·Status: COMPLETED ·Phase: PHASE2
-
HAIC Plus PD-1 Antibody vs HAIC Plus Sorafenib for Advanced HCC
NCT03780634 ·Status: WITHDRAWN ·Phase: PHASE2
-
Anti-PD-1/PD-L1 Antibodies Plus Anti-VEGF Antibody Treatment in Patients With Advanced-Stage HCC
NCT06537908 ·Status: RECRUITING
-
HAIC Plus Lenvatinib and PD-1 Antibody Versus HAIC Plus Lenvatinib for Advanced HCC
NCT03803254 ·Status: WITHDRAWN ·Phase: PHASE2
-
Lenvatinib Plus Sintilimab in Patients With Immune Checkpoint Inhibitor Previously Treated Advanced Liver Cancer
NCT05010681 ·Status: RECRUITING ·Phase: PHASE2
-
Anti-PD-1therapy Combined With Thermal Ablation for Advanced HCC
NCT03939975 ·Status: COMPLETED ·Phase: PHASE2
-
Safety and Efficacy of Lenvatinib in Subjects With HCC Progression After First Line Treatment With Checkpoint Inhibitors
NCT04428437 ·Status: TERMINATED
-
The Study of KN046 in Combination With Lenvatinib in Advanced Hepatocellular Carcinoma
NCT04542837 ·Status: COMPLETED ·Phase: PHASE2
-
Pembrolizumab and Lenvatinib for Resectable Hepatocellular Carcinoma
NCT05389527 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
PD-1 Antibody and Lenvatinib Plus TACE-HAIC for Potential Resectable HCC: a Single-arm, Phase 2 Clinical Trial
NCT04814043 ·Status: UNKNOWN ·Phase: PHASE2
-
Anti-PD-1/PD-L1 Antibodies Plus Pegylated Interferon Alfa-2b Treatment in Patients With Advanced-Stage HCC
NCT04943679 ·Status: UNKNOWN
-
Lenvatinib Plus Tislelizumab Versus Lenvatinib Alone in Hepatocellular Carcinoma Previously Treated With Anti-PD1/PD-L1 and Bevacizumab
NCT07047586 ·Status: RECRUITING ·Phase: PHASE2
-
Lenvatinib, Tislelizumab Combined With RALOX Regimen HAIC in Advanced Hepatocellular Carcinoma
NCT05954897 ·Status: RECRUITING ·Phase: PHASE2
-
RT+ Anti-PD-1 for Patients With Advanced HCC (RT+PD-1-HCC)
NCT04193696 ·Status: UNKNOWN ·Phase: PHASE2
-
Adjuvant Tislelizumab Plus Lenvatinib for Patients at High-risk of HCC Recurrence After Curative Resection or Ablation
NCT05910970 ·Status: NOT_YET_RECRUITING ·Phase: PHASE3
-
A Study to Evaluate SHR-1210 in Subjects With Advanced HCC
NCT02989922 ·Status: COMPLETED ·Phase: PHASE2
-
Lenvatinib for Unresectable Intrahepatic Cholangiocarcinoma
NCT03801499 ·Status: WITHDRAWN ·Phase: PHASE2
-
Phase 2 Study of ADI-PEG 20 Plus Lenvatinib Treatment in Subjects With Unresectable Hepatocellular Carcinoma
NCT06034977 ·Status: RECRUITING ·Phase: PHASE2
-
Anti-PD-1/PD-L1 Antibodies Plus S-adenosyl-methionine Treatment in Patients With Advanced-Stage Hepatocellular Carcinoma
NCT05701553 ·Status: RECRUITING
-
Phase II Study of Concurrent Lenvatinib and Radiotherapy for Advanced HCC
NCT04791176 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Anti-PD-1/CTLA-4 Bispecific AK104 Plus Lenvatinib in First-line Advanced Hepatocellular Carcinoma
NCT04444167 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Lenvatinib Plus Nivolumab Versus Lenvatinib for Advanced Hepatocellular Carcinoma With Hepatitis B Virus Infection
NCT04044651 ·Status: WITHDRAWN ·Phase: PHASE2/PHASE3
-
Safety and Efficacy of Lenvatinib and Anti-PD1 Antibody Combined With Radiotherapy Neoadjuvant Treatment for Resectable Hepatocellular Carcinoma With PVTT
NCT05225116 ·Status: RECRUITING ·Phase: PHASE1
-
PD-1 Monoclonal Antibody, Lenvatinib and TACE in the Treatment of HCC
NCT04273100 ·Status: UNKNOWN ·Phase: PHASE2
-
Real-world Study of Lenalidomide After First-line Treatment Lenvatinib With PD-1 in Advanced HCC
NCT07184424 ·Status: COMPLETED ·Phase: NA