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Prevention of Posttraumatic Osteoarthritis After Acute Intraarticular Fractures

NCT03769909 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 62

Last updated 2018-12-10

No results posted yet for this study

Summary

Intra-articular fracture is a very common fracture. The only method to treat these fractures is surgery with plate and screws followed by rehabilitation. Even though the surgeons do their best to restore the anatomy, up to 40 percent of the patients develop osteoarthritis after 10 years. Previous research has shown that immediately after fracture in the joint, the body starts an inflammatory response and activates a series of biomarkers inside the joint space. Some of these biomarkers are believed to break down the cartilage resulting in development of osteoarthritis, despite surgical treatment. Currently it is still unknown, which biomarkers are activated in the joint space, and how we can stop their deleterious action in order to prevent cartilage degradation.

The purpose of this project is to identify the biomarkers in the joint space after an intra-articular ankle fracture and to evaluate how these biomarkers affect the short- and mid-terms clinical outcomes. As secondary outcomes we evaluate how fracture classification and fracture reduction affect clinical outcomes and physical activity after surgery.

Conditions

Sponsors & Collaborators

  • University of Freiburg

    collaborator OTHER

  • Odense University Hospital

    collaborator OTHER

  • The Danish Rheumatism Association

    collaborator OTHER

  • Hartmann Fonden

    collaborator OTHER

  • AP Møller Fond

    collaborator UNKNOWN

  • University of Southern Denmark

    lead OTHER

Principal Investigators

  • Søren Overgaard, Professor · The Orthopaedic Research Unit

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-10-31
Primary Completion
2020-12-31
Completion
2022-12-31

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03769909 on ClinicalTrials.gov