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Senna Alata Leaf Decoction as a Treatment for Tinea Imbricata

NCT03745183 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2018-11-19

No results posted yet for this study

Summary

Background: Tinea imbricata ("tokelau") is a rare form of tinea corporis which is caused by Trichophyton concentricum. It is endemic among the T'boli tribe in Sarangani, Philippines . Temporary remissions, despite antifungal treatment, can be attributed to factors such as genetic susceptibility, widespread poverty, poor hygienic conditions and overcrowding. Limited access to commercial antifungal medications makes the treatment of tinea imbricata a pressing public health concern.

Senna alata grows abundantly in the areas where the T'boli tribe resides. Anecdotal reports about its efficacy as a treatment for tinea imbricata exist and need to be further validated.

Objective: This study aims to assess the efficacy and safety of a community-prepared Senna alata leaf decoction in the treatment of tinea imbricata.

Methods: This study is a preliminary open label, before and after clinical trial. Enrolled patients were taught how to make Senna alata leaf decoction and were asked to apply it as a leave-on body wash once a day for 28+/-3 days. Disease severity, pruritus visual analogue scale scores (VAS) and potassium hydroxide smear (KOH) of the skin scrapings were evaluated before and after treatment. Two separate assessors evaluated post treatment severity based on standard photographs. Diagnostic concordance was determined using Cohen's kappa statistics. Wilcoxon paired signed-rank test was used to analyzed before and after clinical parameter scores. Adverse drug events were recorded.

Conditions

  • Tinea Imbricata

Interventions

OTHER

Senna alata leaf decoction

Preparation of the akapulko decoction 1. Remove the leaflets from the rachis of a mature leaf. 2. Wash the mature leaflets thoroughly to remove dust, dirt and debris. 3. In the clay, enamel, or stainless steel pot, place one glassful of closely packed chopped leaves (350 ml glass) and add 2 glasses (around 700ml) of clean water . Use the same glass for measuring the leaves and water. 4. Cook the leaves and bring to a rolling boil. 5. When the fluid is reduced to half, remove the decoction from the fire and cool slightly. 6. Strain the mixture using cheesecloth and press the cut leaves in the strainer to make sure to get as much liquid out of them. 7. Place the liquid in a clean container (bottle/jar with cover). Label the container clearly as "Akapulko".

Sponsors & Collaborators

  • Philippine Dermatological Society

    lead NETWORK

Principal Investigators

  • Kathleen E Alpapara, MD · Philippine Dermatological Society

  • Belen L Dofitas, MD · Philippine Dermatological Society

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-11-30
Primary Completion
2015-01-15
Completion
2015-01-15

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03745183 on ClinicalTrials.gov