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Cohort Study of Healthcare Workers Receiving Imvanex®

NCT03745131 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2020-03-03

No results posted yet for this study

Summary

During an outbreak of monkeypox in the UK in 2018, a third generation smallpox vaccine, Imvanex, was used for the first time to immunise healthcare workers who had been, or were expected to be, in contact with cases of monkeypox. This study will examine the antibody responses in these healthcare workers compared to control groups, to provide evidence that the vaccine can produce a response consistent with protection when used in this context.

Conditions

  • Monkeypox

Interventions

OTHER

Blood draw

Blood draw to obtain serum to determine anti-orthopox antibody titres.

Sponsors & Collaborators

  • Bavarian Nordic

    collaborator INDUSTRY

  • Public Health England

    lead OTHER_GOV

Principal Investigators

  • William Jake Dunning, MRCP PhD · Public Health England

  • Meera Chand, FRCPath · Public Health England

  • Sema Mandal, MRCP FFPH · Public Health England

  • Nicholas Andrews, PhD · Public Health England

  • Timothy Brooks, FRCPath · Public Health England

  • Michael Beadsworth, MD MRCP · Liverpool University Hospitals NHS Foundation Trust

  • Michael Jacobs, FRCP PhD · Royal Free London NHS Foundation Trust

  • Matthias Schmid, MD FRCP · Newcastle Hospitals NHS Foundation Trust

  • Christopher Meadows, FRCP FRCA · Guy's and St Thomas' NHS Foundation Trust

  • Peter Flegg, MD FRCP · Blackpool Teaching Hospitals NHS Foundation Trust

  • Heinz Weidenthaler · Bavarian Nordic

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-10-30
Primary Completion
2019-05-30
Completion
2019-11-30

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03745131 on ClinicalTrials.gov