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Disorders of the Acute Phase Response Following Trauma and Invasive Surgery

NCT03741023 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 320

Last updated 2026-03-27

No results posted yet for this study

Summary

The purpose of the proposed study is to test these hypotheses through the following aims:

1. To determine if early plasmin activation following severe injury correlates with SIRS, TIC and complications throughout convalescence in both trauma and surgical patients.
2. To determine if early plasmin activation following severe injury correlates with plasminogen consumption and poor plasmin activity later in convalescence.

Conditions

  • Acute Phase Response

Interventions

PROCEDURE

Blood draw (venipuncture or fingerstick)

Blood will be drawn from participants by venipuncture and/or by fingerstick. Finger sticks will not be collected in the pediatric population.

Sponsors & Collaborators

  • Vanderbilt University Medical Center

    lead OTHER

Principal Investigators

  • Jonathan Schoenecker, MD, PhD · Vanderbilt University Medical Center

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
2 Months
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-12-12
Primary Completion
2027-01-01
Completion
2027-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03741023 on ClinicalTrials.gov