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High Frequency rTMS Over l-DLPFC in Gambling Disorder

NCT03733808 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2020-02-05

No results posted yet for this study

Summary

Gambling disorder (GD), currently considered a behavioral addiction, show substantial similarities with substance use disorders (SUDs) in terms of neurobiology and symptomatology. In particular, alterations in prefrontal control circuit may underlie vulnerability to gambling- and drug-related cues and diminished cognitive control over craving, and negative emotions. Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC) could represent a novel approach to remodel these brain circuits.

The aim of this study is to evaluate High frequency (HF) rTMS over the left DLPFC as an efficacious treatment for reduction of gambling urges and behavior in a randomized double-blind placebo-controlled design in which 36 GD patients will receive active or sham rTMS for 12 weeks.

Conditions

  • Gambling Disorder

Interventions

DEVICE

Repetitive Transcranial Magnetic Stimulation

Non-invasive brain stimulation technique

Sponsors & Collaborators

  • Casa di Cura Park Villa Napoleon

    collaborator UNKNOWN

  • University of Padova

    collaborator OTHER

  • Istituto Italiano di Tecnologia

    collaborator OTHER

  • Fondazione Novella Fronda

    lead OTHER

Principal Investigators

  • Franco Garonna, MD · Casa di Cura Park Villa Napoleon

  • Stefano Cardullo, PhD · Fondazione Novella Fronda

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-12-11
Primary Completion
2021-08-31
Completion
2022-08-31

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03733808 on ClinicalTrials.gov