MedTrace Logo

Intra Articular Injection of Botulinum Toxin Versus Corticoids in Gonarthrosis

NCT03726788 · Status: WITHDRAWN · Phase: PHASE2 · Type: INTERVENTIONAL

Last updated 2025-09-10

No results posted yet for this study

Summary

We believe we can demonstrate a link between the analgesic action of intra-articular injection of botulinum toxin and synovial inflammation by Dynamic Contrast Enhancement (DCE) perfusion Magnetic Resonance Imaging (MRI).

Conditions

  • Joint Diseases
  • Knee
  • Therapeutics
  • Magnetic Resonance Imaging

Interventions

DRUG

Botulinum Toxin Type A 100U

one intra-articular injection of 100 U of botulinum toxin type A, diluted in 2 ml of 0.9% SSI

DRUG

Botulinum Toxin Type A 200U

one intra-articular injection of 200 U of botulinum toxin type A, diluted in 4 ml of 0.9% SSI

DRUG

Triamcinolone Hexacetonide Inj Susp 20 MG/ML

one intra-articular injection of 2 ml Triamcinolone Hexacetonide

Sponsors & Collaborators

  • Allergan

    collaborator INDUSTRY

  • Lille Catholic University

    lead OTHER

Principal Investigators

  • Hichem Khenioui, MD · GHICL

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-09-30
Primary Completion
2021-11-30
Completion
2022-04-30

Countries

  • France

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03726788 on ClinicalTrials.gov