M6620 (VX-970) in Selected Solid Tumors
NCT03718091 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 30
Last updated 2023-07-07
Summary
This research study is studying a drug called M6620 as a possible treatment for advanced solid tumor.
Conditions
- Solid Tumor
- Leiomyosarcoma
- Osteosarcoma
Interventions
- DRUG
-
M6620
M6620 is a drug designed to inhibit the ATR enzyme. Inhibiting ATR may block how cancers repair their naturally damaged DNA, handle cancer cell stress, and maintain cancer cell life and health.
Sponsors & Collaborators
- collaborator INDUSTRY
-
Massachusetts General Hospital
lead OTHER
Principal Investigators
-
Gregory M Cote, MD, PhD · Massachusetts General Hospital
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 12 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2019-01-08
- Primary Completion
- 2020-06-01
- Completion
- 2020-07-08
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Phase 1b/2 Study of AMG 655 With Doxorubicin for the First-Line Treatment of Unresectable Soft Tissue Sarcoma
NCT00626704 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Temozolomide in Treating Patients With Metastatic Non-small Cell Lung Cancer
NCT00006877 ·Status: COMPLETED ·Phase: PHASE2
-
Temozolomide in Patients With Progressive or Recurrent Non-small Cell Lung Cancer
NCT00003062 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of NOX66 Plus Doxorubicin in Anthracycline-naïve, Adult Patients With Soft Tissue Sarcoma
NCT05100628 ·Status: TERMINATED ·Phase: PHASE1
-
Liposomal Irinotecan and Veliparib in Treating Patients With Solid Tumors
NCT02631733 ·Status: COMPLETED ·Phase: PHASE1
-
Avelumab and M6620 for the Treatment of DDR Deficient Metastatic or Unresectable Solid Tumors
NCT04266912 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Nanoparticle Albumin-Bound Rapamycin in Treating Patients With Advanced Cancer With mTOR Mutations
NCT02646319 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
A Study of VEGF-Antisense Oligonucleotide in Combination With Pemetrexed and Cisplatin for the Treatment of Advanced Malignant Mesothelioma
NCT00668499 ·Status: WITHDRAWN ·Phase: PHASE1/PHASE2
-
Pre-operative Mocetinostat (MGCD0103) and Durvalumab (MEDI4736) (PRIMED) for Squamous Cell Carcinoma of the Oral Cavity
NCT02993991 ·Status: WITHDRAWN ·Phase: PHASE1
-
A Phase 1 Dose Escalation Study of VS-5584 Administered in Combination With VS-6063, in Subjects With Relapsed Malignant Mesothelioma
NCT02372227 ·Status: TERMINATED ·Phase: PHASE1
-
Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
NCT02568267 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor Cancer
NCT05859074 ·Status: RECRUITING ·Phase: PHASE1
-
Sorafenib Tosylate, Combination Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With High-Risk Stage IIB-IV Soft Tissue Sarcoma
NCT02050919 ·Status: COMPLETED ·Phase: PHASE2
-
A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies
NCT03652077 ·Status: COMPLETED ·Phase: PHASE1
-
Sarcosinamide Nitrosourea in Treating Patients With Metastatic or Unresectable Solid Tumors
NCT00004079 ·Status: COMPLETED ·Phase: PHASE1
-
SNX-5422 to Treat Solid Tumor Cancers and Lymphomas
NCT00644072 ·Status: COMPLETED ·Phase: PHASE1
-
Temozolomide for Relapsed Sensitive or Refractory Small Cell Lung Cancer
NCT00740636 ·Status: COMPLETED ·Phase: PHASE2
-
Sirolimus in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed By Surgery
NCT01791088 ·Status: COMPLETED ·Phase: PHASE1
-
SARC018: A Study of Mocetinostat and Gemcitabine in Patients With Metastatic Leiomyosarcoma
NCT02303262 ·Status: COMPLETED ·Phase: PHASE2
-
Multi-center, Open Label, Extension Study of ALN-VSP02 in Cancer Patients Who Have Responded to ALN-VSP02 Treatment
NCT01158079 ·Status: COMPLETED ·Phase: PHASE1
-
Phase II Sorafenib With Radiation and Temozolomide in Newly Diagnosed Glioblastoma or Gliosarcoma
NCT02599090 ·Status: WITHDRAWN ·Phase: PHASE2
-
Window of Opportunity Study of VS-6063 (Defactinib) in Surgical Resectable Malignant Pleural Mesothelioma Participants
NCT02004028 ·Status: TERMINATED ·Phase: PHASE2
-
A Pharmacokinetics Study to Investigate the Effect of Ketoconazole on Vemurafenib in Patients With BRAFV600 Mutation-Positive Metastatic Melanoma
NCT01765556 ·Status: WITHDRAWN ·Phase: PHASE1
-
Safety Study of SGX523, a Small Molecule Met Inhibitor, to Treat Solid Tumors
NCT00606879 ·Status: TERMINATED ·Phase: PHASE1
-
SW-682 in Advanced Solid Tumors
NCT06251310 ·Status: RECRUITING ·Phase: PHASE1