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Improving Right Ventricular Function in Young Adults Born Preterm

NCT03696758 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2021-03-17

Study results available
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Summary

The purpose of this research is to evaluate the short-term effects of sildenafil and metoprolol on heart function in young adults born premature.

Conditions

  • Infant,Premature

Interventions

PROCEDURE

Pulmonary Function Testing

Subjects will undergo spirometry, Plethysmography, and diffusion capacity.

PROCEDURE

Electrocardiogram

Subjects will undergo an electrocardiogram to ensure sinus rhythm

PROCEDURE

Cardiac Magnetic Resonance Imaging

Subjects will undergo positron magnetic resonance imaging to detect images of the heart

DRUG

Metoprolol

Subjects will receive intravenous metoprolol. Dose titrated 1-5 mg every 2 minutes to achieve goal heart rate of 55-65 beats per minute, or for subjects with a resting heart rate already at goal, titrated to achieve a 10-15% reduction in heart rate.

DRUG

Sildenafil

Subjects will receive a 50 milligram tablet of sildenafil (to be taken orally)

Sponsors & Collaborators

  • National Center for Advancing Translational Sciences (NCATS)

    collaborator NIH

  • University of Wisconsin, Madison

    lead OTHER

Principal Investigators

  • Kara N Goss, MD · University of Wisconsin-Madison School of Medicine and Public Health

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-10-30
Primary Completion
2020-02-24
Completion
2020-02-24
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03696758 on ClinicalTrials.gov