Safety and Antitumor Activity Study of Loncastuximab Tesirine and Durvalumab in Diffuse Large B-Cell, Mantle Cell, or Follicular Lymphoma
NCT03685344 · Status: TERMINATED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 13
Last updated 2021-10-26
Summary
The purpose of this phase 1 study is to evaluate the safety and anti-tumor activity of Loncastuximab Tesirine (ADCT-402) and Durvalumab in participants with Advanced Diffuse Large B-Cell Lymphoma, Mantle Cell Lymphoma, or Follicular Lymphoma
Conditions
- Diffuse Large B-Cell Lymphoma
- Mantle Cell Lymphoma
- Follicular Lymphoma
Interventions
- DRUG
-
Loncastuximab Tesirine and Durvalumab
intravenous infusion
Sponsors & Collaborators
-
ADC Therapeutics S.A.
lead INDUSTRY
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2019-02-04
- Primary Completion
- 2020-10-27
- Completion
- 2020-10-27
- FDA Drug
- Yes
Countries
- United States
- Spain
Study Locations
More Related Trials
-
Loncastuximab Tesirine in Combination With DA-EPOCH-R in Patients With Previously Untreated Aggressive B-cell Lymphoid Malignancies
NCT05270057 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Trial of Loncastuximab Tesirine in High Risk Diffuse Large B-cell Lymphoma Post Transplant
NCT05222438 ·Status: WITHDRAWN ·Phase: PHASE2
-
Combining Loncastuximab Tesirine and Epcoritamab in Relapsed/Refractory Diffuse Large B-cell Lymphoma (DLBCL)
NCT07197307 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Tafasitamab + Lenalidomide + R-CHOP Versus R-CHOP in Newly Diagnosed High-intermediate and High Risk DLBCL Patients
NCT04824092 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
DLCL002 Protocol for Patients With High Risk Aggressive B-cell Lymphoma
NCT03837873 ·Status: UNKNOWN ·Phase: PHASE2
-
Ph I/II Study of E7777 Prior to CAR-T for R/R LBCL
NCT04855253 ·Status: SUSPENDED ·Phase: PHASE1/PHASE2
-
Consolidation With Loncastuximab Tesirine After a Short Course of Immunochemotherapy in BTKi-treated (or Intolerant) Relapsed/Refractory Mantle Cell Lymphoma Patients.
NCT05249959 ·Status: RECRUITING ·Phase: PHASE2
-
Loncastuximab Tesirine in Combination With Chemotherapy Prior to Stem Cell Transplant for the Treatment of Recurrent or Refractory Diffuse Large B-Cell Lymphoma
NCT05228249 ·Status: WITHDRAWN ·Phase: PHASE1
-
A Study to Evaluate the Tolerability, Safety, Pharmacokinetics, and Antitumor Activity of Loncastuximab Tesirine in Combination With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated Diffuse Large B-cell Lymphoma (LOTIS-8)
NCT04974996 ·Status: WITHDRAWN ·Phase: PHASE1
-
Study of Tisagenlecleucel in Combination With Ibrutinib in r/r Diffuse Large B-cell Lymphoma Patients
NCT03876028 ·Status: TERMINATED ·Phase: PHASE1
-
Durvalumab in Different Combinations With Pralatrexate, Romidepsin and Oral 5-Azacitidine for Lymphoma
NCT03161223 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Novel Combinations of CC-122, CC-223, CC-292, and Rituximab in Diffuse Large B-cell Lymphoma and Follicular Lymphoma
NCT02031419 ·Status: TERMINATED ·Phase: PHASE1
-
Effect of Blinatumomab on Minimal Residual Disease (MRD) in Diffuse Large B-Cell Lymphoma (DLBCL) Subjects Post Autologous Hematopoietic Stem Cell Transplantation (aHSCT)
NCT03298412 ·Status: TERMINATED ·Phase: PHASE2
-
Loncastuximab Tesirine and Rituximab Followed by DA-EPOCH-R for Treating Patients With High-Risk Diffuse Large B-cell Lymphoma
NCT05600686 ·Status: RECRUITING ·Phase: PHASE2
-
Tislelizumab in Combination With Lenalidomide in Refractory and Relapsed Elderly Patients With Non-GCB DLBCL
NCT04796857 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Real Time Molecular Characterization of Diffuse Large B Cell Lymphoma (DLBCL)
NCT03104478 ·Status: COMPLETED
-
A Safety and Pharmacology Study of Atezolizumab (MPDL3280A) Administered With Obinutuzumab or Tazemetostat in Participants With Relapsed/Refractory Follicular Lymphoma and Diffuse Large B-cell Lymphoma
NCT02220842 ·Status: COMPLETED ·Phase: PHASE1
-
Dynamic CtDNA-guided Targeted Therapy in DLBCL
NCT06748521 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Study to Evaluate the Efficacy and Safety of Loncastuximab Tesirine Versus Idelalisib in Participants With Relapsed or Refractory Follicular Lymphoma
NCT04699461 ·Status: TERMINATED ·Phase: PHASE2
-
Decitabine Plus R-CHOP in Diffuse Large B-cell Lymphoma
NCT02951728 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Dose Dense Chemotherapy + Rituximab +/-Intensified High Dose Chemoimmunotherapy With Support of Peripheral Autologous Stem Cell in Diffuse Large B-Cell Lymphoma
NCT00499018 ·Status: UNKNOWN ·Phase: PHASE3
-
Efficacy and Safety Study of Lenalidomide Plus R-CHOP Chemotherapy Versus Placebo Plus R-CHOP Chemotherapy in Untreated ABC Type Diffuse Large B-cell Lymphoma
NCT02285062 ·Status: COMPLETED ·Phase: PHASE3
-
Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of Duvortuxizumab (JNJ-64052781) Plus Ibrutinib in Lymphoma
NCT02743546 ·Status: WITHDRAWN ·Phase: PHASE1
-
A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas
NCT05475925 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Rituximab and Combination Chemotherapy With or Without Lenalidomide in Treating Patients With Newly Diagnosed Stage II-IV Diffuse Large B Cell Lymphoma
NCT01856192 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2