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Assessment of 2 Different Techniques for Suppression of Respiratory Motion in Lung Cancer Treatment With Proton Therapy Using Magnetic Resonance Imaging (MRI)

NCT03669341 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2021-06-09

No results posted yet for this study

Summary

Since 1996 proton therapy has been applied very successfully at the Paul Scherrer Institute in Switzerland to irradiate deep-seated, stationary tumors. In order to treat tumors within an organ which moves due to breathing (e.g. lung) motion mitigation strategies need to be implemented to ensure the precise irradiation of the moving target. The aim of this study is to assess the feasibility and compare (via MRI imaging) 2 techniques which "freeze" the movement of the lung by breath hold. One method is suppression of respiratory movement via high-frequency, mechanical ventilation by means of a Jet Ventilator (HFPV). The other technique is deep Inspiration breath-hold (DIBH) with Hyperventilation and simultaneous Inspiration of 100% O2 including daily breath-hold exercise.

Conditions

  • Healthy Volunteers

Interventions

OTHER

Deep Inspiration Breath Hold (DIBH)

human-based DIBH method with short-term breath-hold training

OTHER

High Frequency Percussive Ventilation (HFPV)

device-based HFPV technique

Sponsors & Collaborators

  • Swiss Federal Institute of Technology

    collaborator OTHER

  • Paul Scherrer Institut, Center for Proton Therapy

    lead OTHER

Principal Investigators

  • Frank Emert, PhD · Paul Scherrer Institut, Center for Proton Therapy

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SEQUENTIAL

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-10-10
Primary Completion
2019-03-11
Completion
2019-08-14

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03669341 on ClinicalTrials.gov