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Effects of Epidural Block on the Prognosis in Patients With Pancreatic Cancer Undergoing Distal Pancreatectomy

NCT03659292 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 540

Last updated 2018-09-06

No results posted yet for this study

Summary

The purpose of this randomized controlled clinical trial is to investigate the effects of epidural block on overall survival，disease-free survival and recovery in patients with pancreatic cancer undergoing distal pancreatectomy. This study will also evaluate the effects of this technique on neuroendocrine, stress and inflammatory response in these patients.

Conditions

  • Cancer of Pancreas

Interventions

OTHER

GEA

Thoracic epidural catheterization will be performed and epidural anesthesia will be maintained with 0.25% ropivacaine during surgery. General anesthesia will be maintained with inhalation (sevoflurane) and muscle relaxants will be administered when considered necessary.

OTHER

PCEA

Patient-controlled epidural analgesia (0.15% ropivacaine and 0.5ug/ml sufentanil infusion) will be provided after surgery.

OTHER

GA

General anesthesia will be maintained with inhalation (sevoflurane) and sufentanil infusion, and muscle relaxants will be administered when considered necessary.

OTHER

PCIA

Patient-controlled intravenous analgesia (1ug/ml sufentanil) will be provided after surgery.

Sponsors & Collaborators

  • Washington University School of Medicine

    collaborator OTHER

  • Fudan University

    lead OTHER

Principal Investigators

  • Changhong Miao · Fudan University

  • Qianjin Liu · Washington University School of Medicine

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-09-30
Primary Completion
2022-10-31
Completion
2022-10-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03659292 on ClinicalTrials.gov