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New Periodontitis Treatment Based on Hyaluronic Acid and Melatonin

NCT03656484 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2020-01-27

No results posted yet for this study

Summary

The aim of the present study is to determine whether the association of Melatonin and Hyaluronic Acid to the antimicrobial TM paste (3% Tetracyclin and 3% Metronidazole) for periodontal maintenance therapy can improve the attachment level (AL) and alveolar bone support for moderate chronic periodontitis.

Conditions

  • Chronic Periodontitis

Interventions

DRUG

Tetracycline-Metronidazole (TM) group

Following mechanical debridement (scaling and root planning) the above-mentioned paste will be topically administrated in the periodontal pocket of affected teeth once a day, for 30 consecutive days.

DRUG

TM-Melatonin-Hyaluronic acid (TM-MHa) group

Following mechanical debridement (scaling and root planning) the above-mentioned paste will be topically administrated in the periodontal pocket of affected teeth once a day, for 30 consecutive days.

Sponsors & Collaborators

  • Carol Davila University of Medicine and Pharmacy

    collaborator OTHER

  • Romanian National Authority for Scientific Research and Innovation (UEFISCIDI)

    collaborator UNKNOWN

  • University Politechnica of Bucharest

    collaborator UNKNOWN

  • TURKEY MEDISEN Ltd

    collaborator UNKNOWN

  • Concordia Dent Srl

    lead OTHER

Principal Investigators

  • CORINA MARILENA CRISTACHE · Carol Davila University of Medicine and Pharmacy

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-01-15
Primary Completion
2019-12-20
Completion
2019-12-20

Countries

  • Romania

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03656484 on ClinicalTrials.gov