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Radiation Therapy Planning by Multi-parametric PET/MRI Imaging in Patients With Cervical Cancer

NCT03655977 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 25

Last updated 2018-09-04

No results posted yet for this study

Summary

The main goal of this project is to evaluate the potential and feasibility of hybrid PET/MRI functional imaging to non-invasively measure tumor characteristics for radiation therapy planning (RT) for cervical cancer. It will be assessed how the complementary information of tumor characteristics can contributed to better understanding of tumor delineation. Another endpoint of this study is to evaluate a new PET-tracer (68Ga-NODAGA- E\[c(RGDyK)\]2) enabling imaging of tumor-angiogenesis.

Conditions

Interventions

DRUG

68Ga-NODAGA-E[c(RGDyK)]2

200 MBq 68Ga-NODAGA-E\[c(RGDyK)\]2 will be administered before external beam radiation therapy (EBRT).

DEVICE

PET/MRI scan instead of only MRI

Following injection of RGD-PET the patients will be subjected to PET/MRI of the pelvic for planning external beam radiation therapy.

DRUG

68Ga-NODAGA-E[c(RGDyK)]2

200 MBq 68Ga-NODAGA-E\[c(RGDyK)\]2 will be administered before brachytherapy (BT).

DEVICE

PET/MRI scan instead of only MRI

Following injection of RGD-PET the patients will be subjected to PET/MRI of the pelvic for planning brachytherapy.

Sponsors & Collaborators

  • Rigshospitalet, Denmark

    lead OTHER

Principal Investigators

  • Barbara Malene Fisher · Dept. of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-09-01
Primary Completion
2021-09-01
Completion
2021-09-01

Countries

  • Denmark

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03655977 on ClinicalTrials.gov