Integral Remediation for Major Depression ("Rehabilitación Integral Para la Depresión Mayor", RIDEM)

Summary

Available pharmacological and psychotherapeutic treatments are not effective for the treatment of cognitive symptoms of major depressive disorder (MDD). More recent studies have described that functional disability and the indirect costs of MDD (e.g., sick leaves at work, decreased productivity, ...) are related to persistent cognitive deficits. Some programs of cognitive rehabilitation and cognitive training (developed for other pathologies) have been tested, but the results are inconsistent.

There is an imperative need to develop a specific comprehensive rehabilitation program for MDD that includes the benefits of traditional functional remediation (FR) and computerized cognitive training (CCT) programs adjusted for each patient's cognitive deficit.

Conditions

• Major Depressive Disorder
• Cognitive Symptom

Interventions

BEHAVIORAL

Functional Remediation

Functional remediation includes directed group sessions tapping into the main cognitive domains affected in depression (executive functioning, attention and memory) as well as their implication in daily living.

DEVICE

Computerized Cognitive Training (CCT)

12 add-on sessions (20-minute long) after each group session to train cognitive domains.

BEHAVIORAL

Psychoeducation

12 sessions of psychoeducation on depression, providing information about the disease, causes, consequences and other useful data for the management of depression.

DEVICE

Online games

Participants play non-directed online games during 20 minutes after each psychoeducation grup session to make the two active intervention more similar.

Sponsors & Collaborators

• Instituto de Salud Carlos III

  collaborator OTHER_GOV

• Hospital de Sant Pau

  lead OTHER

Principal Investigators

• Maria J Portella, Dr · IBB-Sant Pau

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-03-15

Primary Completion

2020-10-31

Completion

2020-12-31

Countries

• Spain

Study Locations