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Vitamin D Homeostasis in Sarcoidosis

NCT03621553 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2026-01-02

No results posted yet for this study

Summary

This study evaluates the relationship between vitamin-D status and severity of sarcoidosis, and the effects of vitamin-D repletion in vitamin-D insufficient patients with sarcoidosis. Half the patients with sarcoidosis who are vitamin-D insufficient will receive standard vitamin-D supplementation via standard regimen while the other half will receive a placebo. Sarcoidosis patients who are vitamin-D sufficient will also act as controls.

Conditions

  • Sarcoidosis
  • Vitamin D Insufficiency

Interventions

DRUG

Calcium Citrate with Vitamin D2

To meet the recommended minimum daily dietary requirements

DRUG

Ergocalciferol

Vitamin D2 50,000 units

DRUG

Placebo

Sugar pill manufactured to mimic ergocalciferol 50,000 units

Sponsors & Collaborators

  • University of Texas Southwestern Medical Center

    lead OTHER

Principal Investigators

  • Connie Hsia, MD · University of Texas Southwestern Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
21 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-07-01
Primary Completion
2026-02-28
Completion
2026-12-30
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03621553 on ClinicalTrials.gov