Interventions to Improve HIV Antiretroviral Therapy Adherence

Summary

This study will explore whether financial incentives, reminders, information about HIV/AIDS and its treatment and anti-stigma counseling help improve anti-retroviral therapy (ART) adherence among HIV infected individuals in a resource-limited environment. The interventions will be randomized in the study population in a cross-cutting design, with a control group, a financial incentive treatment group, a reminders treatment group, a treatment group that receives both the financial incentive and reminder interventions. In addition, there will be an information treatment group, a stigma-relieving treatment group and a group that receives both information and stigma-relieving interventions. The primary outcomes of interest for this study will be the adherence to ART, measured by attendance rates at clinic appointments and refill collection rates.

Conditions

• Human Immunodeficiency Virus (HIV) Infection

Interventions

BEHAVIORAL

Financial Incentive

Financial Incentive: Participants will receive monthly financial incentives each time they refill the ART medication on time for six months

BEHAVIORAL

Reminders

Reminders: Participants will receive monthly reminder phone calls before their ART medication refill is due for six months.

BEHAVIORAL

Financial Incentive and Reminders

Interaction: Participants receive both the Financial Incentives and Reminder Calls.

BEHAVIORAL

Information

Information: show the participants a video about HIV progression, mechanism of ART, the benefit of adhering to ART.

BEHAVIORAL

Stigma-relieving

Stigma-Reliving: Upon recruitment, inform the participants of the results of a recent population survey regarding people's attitudes towards HIV, if they overestimate the social stigma related to HIV. This intervention intends to reduce the stigma-concern faced by the patients.

BEHAVIORAL

Information and Stigma-relieving

Information and Stigma-relieving: Upon recruitment, show the participants a video about HIV progression, mechanism of ART, the benefit of adhering to ART. In addition, inform the participants of the results of a recent population survey regarding people's attitudes towards HIV, if they overestimate the social stigma related to HIV. This intervention intends to reduce the stigma-concern faced by the patients.

Sponsors & Collaborators

• Beira Operational Research Center

  collaborator UNKNOWN

• University of Michigan

  lead OTHER

Principal Investigators

• James Riddell IV, MD · University of Michigan

Study Design

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-08-06

Primary Completion

2021-04-30

Completion

2021-04-30

Countries

• Mozambique

Study Locations