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Study of the Expression of MMPs in OME in Children With Atrophy of the Eardrum

NCT03611842 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 35

Last updated 2019-04-19

No results posted yet for this study

Summary

Metalloproteinases (MMPs) constitute a family of endopeptidases that cleaves the extracellular matrix as collagen included in the eardrum. Activity of MMP has been shown in some otitis media with effusion (OME) fluids. These enzymes could be directly linked to the prosnostic of OME as it may damage the eardrum and leads to tympanic atrophy.

The main goal of the study is to find out the correlation between activity of MMPs and tympanic atrophy. The investigator will also study if there is any clinical predictive factors in relation to the level of MMPs.

Conditions

  • Otitis Media With Effusion

Interventions

OTHER

preservation of mucosal otitis media

Suction of the middle ear fluid and conservation of the fluid to be collected instead of thrown away into children Healthy eardrum and Atrophic eardrum

Sponsors & Collaborators

  • INM : institut des neurosciences Montpellier

    collaborator UNKNOWN

  • University Hospital, Montpellier

    lead OTHER

Principal Investigators

  • Lylou Casteil Baume, ENT resident · University Hospital, Montpellier

Eligibility

Max Age
12 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-09-30
Primary Completion
2018-11-01
Completion
2018-11-30

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03611842 on ClinicalTrials.gov