Bioclinical Study of Scalp Photoaging of a Population Male Over 65 Years Old.

Summary

The aging of skin, especially that of the scalp, is a combination of intrinsic and extrinsic aging factors secondary to the chronic sun exposure. For men with an alopecia genetic (= bald men), the solar part, in skin aging process, is major.

The helio-dermal scalp is frequently the site of cancers mainly after 65 years. Objectives are to identify specific biomarkers involved in the photo-aging of the alopecic scalp

Conditions

• Skin Aging
• Skin Cancer

Interventions

PROCEDURE

biopsy

Biopsy 4 to 5 mm from the distal part of the tips of the excision pieces. Three biopsies of 3 mm, made with punch, occipital hair zone (ZT) A completely painless sample, using a swab (soaked with a buffer solution) on the scalp of the ZH and ZT zone.

DIAGNOSTIC_TEST

blood sample

Blood sample will be collected for performed for HIV serology, B and C hepatitis.

DIAGNOSTIC_TEST

questionnaire on sun exposure

Questionnaire on sun exposure will be completed by patients.

DIAGNOSTIC_TEST

examination of the scalp

A complete examination of the scalp will be completed by dermatologist.

DIAGNOSTIC_TEST

Norwood scale

Norwood scale measure the evolution of baldness. It will be completed by dermatologist.

DIAGNOSTIC_TEST

questionnaire of clinicals signs

Questionnaire of clinicals signs will be completed by dermatologist and patient.

DIAGNOSTIC_TEST

scinexa score

It's a assessment score of skin aging. It will be completed by dermatologist.

DIAGNOSTIC_TEST

questionnaire of the history of the hair loss

Questionnaire of the history of the hair loss will be completed by dermatologist and patient.

Sponsors & Collaborators

• Pierre Fabre Dermo Cosmetique

  collaborator INDUSTRY

• Centre Hospitalier Universitaire de Saint Etienne

  lead OTHER

Principal Investigators

• JEAN LUC PERROT, MD · CHU SAINT-ETIENNE

Study Design

Allocation

NA

Purpose

OTHER

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

65 Years

Sex

MALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-02-14

Primary Completion

2019-09-20

Completion

2019-09-20

Countries

• France

Study Locations