Gut Microbes and Metabolic Group in Different PBC Patients for UDCA Response
NCT03590886 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 60
Last updated 2019-12-24
Summary
To compare intestinal flora diversity in different PBC patients with UDCA responses, and further study the differences of bile acid metabolism and short chain fatty acid metabolism in feces and serum of two groups of PBC patients.
Conditions
- Primary Biliary Cirrhosis
Interventions
- OTHER
-
total response Group
biochemical response for UDCA treatment more than 1 year according to Paris-I/II standard
Sponsors & Collaborators
-
Sun Yat-sen University
lead OTHER
Principal Investigators
-
Lin B Liang, MD · Third Affliated Hospital of Sun Yat-sen University
Eligibility
- Min Age
- 30 Years
- Max Age
- 70 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2018-08-22
- Primary Completion
- 2018-12-31
- Completion
- 2019-02-28
Countries
- China
Study Locations
More Related Trials
-
CS0159 in Chinese Patients With PBC (Primary Biliary Cholangitis)
NCT05896124 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Study of Obeticholic Acid(OCA) Combination With Ursodeoxycholic Acid (UDCA) in Patients With Primay Biliary Cirrhosis (PBC)
NCT04956328 ·Status: UNKNOWN ·Phase: PHASE3
-
Fecal Microbiota Transplantation for Decompensated Cirrhosis
NCT03014505 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Fenofibrate in Patients With Primary Biliary Cholangitis (PBC)
NCT06365424 ·Status: RECRUITING ·Phase: PHASE2/PHASE3
-
Performance of Scoring Systems in Chinese Patients With Primary Biliary Cholangitis (PBC) on Ursodeoxycholic Acid
NCT03188146 ·Status: COMPLETED
-
Study of [14C]CS0159 in China Healthy Subjects
NCT06098027 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of CS0159 in Patients With PBC With Inadequate Response or Intolerance to UDCA
NCT07282353 ·Status: RECRUITING ·Phase: PHASE3
-
Efficacy and Safety of Fenofibrate Combined With UDCA in PBC Patients With an Incomplete Biochemical Response to UDCA
NCT02965911 ·Status: WITHDRAWN ·Phase: PHASE1/PHASE2
-
Fenofibrate Combined With Ursodeoxycholic Acid in Subjects With Primary Biliary Cholangitis
NCT05751967 ·Status: RECRUITING ·Phase: PHASE3
-
A 5-year Longitudinal Observational Study of Patients With Primary Biliary Cholangitis
NCT02932449 ·Status: COMPLETED
-
Clinical Research of Tapering UDCA in PBC Patients With a Complete Response
NCT04650243 ·Status: RECRUITING ·Phase: PHASE4
-
Fenofibrate for Compensated Cirrhosis Patients With Primary Biliary Cholangitis
NCT05749822 ·Status: RECRUITING ·Phase: PHASE2/PHASE3
-
Ursodeoxycholic Acid Combined With Low Dose Glucocorticoid in the Treatment of PBC With AIH Features II
NCT04617561 ·Status: UNKNOWN ·Phase: PHASE4
-
Obeticholic Acid Versus Placebo, in Combination with Ursodeoxycholic Acid in Patients with Primary Biliary Cirrhosis
NCT06715319 ·Status: COMPLETED ·Phase: PHASE3
-
Remedial Mechanism of Simvastatin and Ursodeoxycholic Acid in Liver Cirrhosis: Crosstalk of Bile Secretion, Gut Microbiome, and Host Immune Response
NCT07102979 ·Status: ENROLLING_BY_INVITATION ·Phase: NA
-
Evaluation of the Effectiveness of the Use of a Carnitine-Orotate Complex and Biphenyl Dimethyl Dicarboxylate in the Pathogenetic Therapy of Metabolic-associated Fatty Liver Disease: a Prospective Cohort Study
NCT06078722 ·Status: UNKNOWN
-
Microbiome-Mediated Gut Dysfunction in Non-Alcoholic Fatty Liver Disease
NCT05209100 ·Status: COMPLETED
-
A Study in Reversing Hepatic Fibrosis or Cirrhosis Related to Hepatitis B Virus and Finding Biomarkers
NCT03568578 ·Status: UNKNOWN ·Phase: NA
-
Fenofibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cholangitis: a Real World Study
NCT06755541 ·Status: RECRUITING ·Phase: PHASE3
-
Efficacy and Safety of Obeticholic Acid in the Treatment of Primary Biliary Cholangitis
NCT05450887 ·Status: COMPLETED ·Phase: PHASE3
-
Fenofibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cholangitis
NCT06174402 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2/PHASE3
-
Fenofibrate in Subjects With Primary Biliary Cholangitis (PBC)
NCT07104201 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Fecal Microbiota Transplantation (FMT) in Nonalcoholic Steatohepatitis(NASH). A Pilot Study
NCT02469272 ·Status: UNKNOWN ·Phase: PHASE1
-
Efficacy and Safety Study of Allogenic Mesenchymal Stem Cells for Patients With Refractory Primary Biliary Cirrhosis
NCT01440309 ·Status: UNKNOWN ·Phase: PHASE1
-
Fenofibrate for Patients With Primary Biliary Cirrhosis Who Had An Inadequate Response to Ursodeoxycholic Acid
NCT02823366 ·Status: UNKNOWN ·Phase: PHASE3