Pembrolizumab in Relapsed or Refractory Extranodal NK/T- Cell Lymphoma, Nasal Type and EBV-associated Diffuse Large B Cell Lymphomas
NCT03586024 · Status: WITHDRAWN · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL
Last updated 2021-05-07
Summary
To determine the safety and efficacy (overall response rate) of pembrolizumab in patients with relapsed or refractory ENKTL, and EBV-DLBCL
Conditions
Interventions
- DRUG
-
dose of pembrolizumab will be 200 mg IV every 3 weeks
Sponsors & Collaborators
-
Abramson Cancer Center at Penn Medicine
lead OTHER
Principal Investigators
-
Stephen Schuster, MD · Abramson Cancer Center at Penn Medicine
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2019-03-12
- Primary Completion
- 2020-08-19
- Completion
- 2020-08-19
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Study of Pembrolizumab (MK-3475) in Participants With Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma or Relapsed or Refractory Richter Syndrome (MK-3475-170/KEYNOTE-170)
NCT02576990 ·Status: COMPLETED ·Phase: PHASE2
-
Pembrolizumab and Pralatrexate in Treating Patients With Relapsed or Refractory Peripheral T-Cell Lymphomas
NCT03598998 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Nivolumab in Treating Patients With Relapsed or Refractory Peripheral T-cell Lymphoma
NCT03075553 ·Status: TERMINATED ·Phase: PHASE2
-
Treatment of Relapsed or Refractory Natural Killer/T Cell Lymphoma
NCT03107962 ·Status: UNKNOWN ·Phase: PHASE2
-
Pembrolizumab Alone or With Idelalisib or Ibrutinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Other Low-Grade B-Cell Non-Hodgkin Lymphomas
NCT02332980 ·Status: COMPLETED ·Phase: PHASE2
-
Pembrolizumab and Ibrutinib in Treating Patients With Relapsed or Refractory Non-Hodgkin Lymphoma
NCT02950220 ·Status: COMPLETED ·Phase: PHASE1
-
Pembrolizumab and External Beam Radiation Therapy in Treating Patients With Relapsed or Refractory Non-Hodgkin Lymphoma
NCT03210662 ·Status: COMPLETED ·Phase: PHASE2
-
Fludarabine, Pixantrone and Rituximab vs Fludarabine and Rituximab forRelapsed or Refractory Indolent NHL
NCT00577161 ·Status: WITHDRAWN ·Phase: PHASE3
-
Phase I/II Study of Abraxane in Recurrent and Refractory Lymphoma
NCT01555853 ·Status: TERMINATED ·Phase: PHASE1
-
Pembrolizumab and Brentuximab Vedotin in Subjects With Relapsed/Refractory T-cell Lymphoma
NCT05313243 ·Status: RECRUITING ·Phase: PHASE2
-
Panobinostat in Treating Patients With Relapsed or Refractory Non-Hodgkin Lymphoma
NCT01261247 ·Status: COMPLETED ·Phase: PHASE2
-
Akt Inhibitor MK2206 in Treating Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
NCT01481129 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Atezolizumab in Combination With an Immunotherapy Agent Investigated With or Without Anti-Cd20 Therapy in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma
NCT03369964 ·Status: WITHDRAWN ·Phase: PHASE1
-
An Open-Label Phase 2 Trial of Nanatinostat Plus Valganciclovir in Patients With EBV+ Relapsed/Refractory Lymphomas
NCT05011058 ·Status: TERMINATED ·Phase: PHASE2
-
A Phase II Study of Linperlisib (YY-20394) in Patients With Relapsed or Refractory Peripheral T/NK Cell Lymphoma
NCT05274997 ·Status: UNKNOWN ·Phase: PHASE2
-
Study of Pembrolizumab Combined With Decitabine and Pralatrexate in PTCL and CTCL
NCT03240211 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Javelin Parp Medley: Avelumab Plus Talazoparib In Locally Advanced Or Metastatic Solid Tumors
NCT03330405 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Atezolizumab in Combination With Entinostat and Bevacizumab in Patients With Advanced Renal Cell Carcinoma
NCT03024437 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
An Efficacy and Safety Proof of Concept Study of Daratumumab in Relapsed/Refractory Mantle Cell Lymphoma, Diffuse Large B-Cell Lymphoma, and Follicular Lymphoma
NCT02413489 ·Status: TERMINATED ·Phase: PHASE2
-
Study of Pembrolizumab (MK-3475) in Participants With Relapsed or Refractory Classical Hodgkin Lymphoma (MK-3475-087/KEYNOTE-087)
NCT02453594 ·Status: COMPLETED ·Phase: PHASE2
-
Pembrolizumab in Combination With Salvage Chemotherapy for First-relapsed or Refractory Classical Hodgkin Lymphoma
NCT04838652 ·Status: RECRUITING ·Phase: PHASE2
-
Umbralisib and Pembrolizumab in Treating Patients With Relapsed or Refractory Classical Hodgkin Lymphoma
NCT03776864 ·Status: TERMINATED ·Phase: PHASE2
-
A Study to Evaluate the Safety and Efficacy of Pembrolizumab (MK-3475) Coformulated With Berahyaluronidase Alfa (MK-3475A) in Participants With Relapsed or Refractory Classical Hodgkin Lymphoma (rrcHL) or Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma (rrPMBCL)(MK-3475A-F65)
NCT06504394 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study of INCB059872 in Relapsed or Refractory Ewing Sarcoma
NCT03514407 ·Status: TERMINATED ·Phase: PHASE1
-
A Study of Subcutaneously Injected Epcoritamab Plus Oral Lenalidomide Tablets Compared to Intravenously (IV) Infused Rituximab Plus IV Infused Gemcitabine and IV Infused Oxaliplatin in Adult Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
NCT06508658 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3