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Deferred or Immediate Stent Implantation Based on Microvascular Function in STEMI

NCT03581513 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 629

Last updated 2022-07-01

No results posted yet for this study

Summary

Timely percutaneous coronary intervention (PCI) with stenting implantation is the current standard treatment for patients with ST-segment elevation myocardial infarction (STEMI). However, stenting in thrombus-laden artery is associated with higher risk of embolization and no-or slow-reflow, leading to larger infarct size and poor prognosis. The SALVAGE study is a prospective, multicenter, randomized, controlled study aimed to optimize the therapeutic strategies (deferred vs. immediate stenting) to protect microvascular function and eventually improve clinical outcomes at 12-months in STEMI.

Conditions

  • Microcirculatory Perfusion
  • ST Elevation Myocardial Infarction

Interventions

PROCEDURE

Deferred or Immediate Stent Implantation

IMR can be used to measure the microcirculatory resistance of coronary artery. It is not clear whether the IMR value could determine the time of PCI for STEMI patients.

Sponsors & Collaborators

  • The Second Hospital of Hebei Medical University

    collaborator OTHER

  • Jiamusi City Central Hospital

    collaborator UNKNOWN

  • Mudanjiang cardiovascular hospital

    collaborator UNKNOWN

  • Shuangyashan Mining Hospital

    collaborator UNKNOWN

  • First Affiliated Hospital of Jiamusi University

    collaborator UNKNOWN

  • Daqing Longnan Hospital

    collaborator UNKNOWN

  • Beijing Anzhen Hospital

    collaborator OTHER

  • Harbin Medical University

    lead OTHER

Principal Investigators

  • Bo Yu · The Second Affiliated Hospital of Harbin Medical University

  • Xinshun Gu · The Second Hospital of Hebei Medical University

  • Lixin Lu · Daqing Longnan Hospital

  • Zhiyuan Weng · Jiamusi City Central Hospital

  • Kai Liu · Mudanjiang cardiovascular hospital

  • Hui Li · Shuangyashan Mining Hospital

  • Shan Gao · the first affiliated hospital of Jiamusi university

  • ChunMei Wang · Beijing An Zhen Hospital, Capital Medical University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-12-20
Primary Completion
2021-08-31
Completion
2021-08-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03581513 on ClinicalTrials.gov